Cellular, Histologic, and Molecular Changes Associated With Endometriosis and Ovarian Cancer

João Siufi Neto, Rosanne M. Kho, Kho RM, Siufi DF, Daniela Freitas dos Santos Siufi, Edmund Chada Baracat, Baracat EC, Karen S. Anderson, Anderson KS, Maurício Simões Abrão, Abrão MS
Journal of Minimally Invasive Gynecology · 2013 · vol. 21(1) , pp. 55–63 · doi:10.1016/j.jmig.2013.07.021 · PMID:23962574 · W2082381246
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This study investigated the cellular, histologic, and molecular alterations observed in both endometriosis and ovarian cancer tissues.

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Abstract

Our understanding of the pathogenesis of endometriosis is rapidly evolving as early molecular events are increasingly identified. Endometriosis is associated with increased risk of ovarian cancer and exhibits neoplastic phenotypes including invasion of stromal tissue and lymphatic spread to distant organs. This review of the literature establishes the clinical, epidemiologic, and pathologic correlation between endometriosis and low-grade ovarian cancer. Genetic studies have demonstrated that endometriotic lesions have mutations in genes directly related to neoplasms, in particular the p53, KRAS, PTEN, and ARID1A genes, which suggests a direct transition from a subset of endometriotic lesions to invasive carcinomas. The identification of both genetic and epigenetic biomarkers including microRNAs are essential for identifying patients at risk for the transition to neoplasia.

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Condition tags

endometriosis

MeSH descriptors

Carcinoma Endometriosis Ovarian Neoplasms Carcinoma Carcinoma Carcinoma Endometriosis Endometriosis Endometriosis Female Humans Mutation Ovarian Neoplasms Ovarian Neoplasms Ovarian Neoplasms

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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