Decreased expression of FOXA2 promotes eutopic endometrial cell proliferation and migration in patients with endometriosis

Anping Lin, Lin A, Yin J, Juan Yin, Juan Juan Yin, Chao Cheng, Zhu Yang, Yang Z, Yang H, Huan Yang
Reproductive biomedicine online · 2017 · vol. 36(2) , pp. 181–187 · doi:10.1016/j.rbmo.2017.11.001 · PMID:29233503 · W2770765554
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Reduced expression of FOXA2 in eutopic endometrial cells was linked to increased proliferation and migration, potentially contributing to endometriosis.

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Abstract

Endometriosis is characterized by eutopic endometrial cell 'metastasis' to ectopic foci. FOXA2 is a member of the forkhead transcription factor family, which may participate in transcriptional regulation in endometrial cells and contribute to the aetiology of endometriosis. This study investigated the roles played by FOXA2 in eutopic endometrium using endometriosis samples. Western blotting showed that the relative expression of FOXA2 was significantly reduced in eutopic endometrium from patients with endometriosis (n = 14) compared with endometriosis-free controls (n = 16) (0.69 ± 0.07 versus 1.24 ± 0.06, P < 0.05). To mimic eutopic endometrium of endometriosis, primary eutopic endometrial stromal cells (ESC) of controls were harvested and transfected with FOXA2 siRNA. MTT assay showed that cell viability of ESC with transfected FOXA2 siRNA increased significantly, whereas the apoptosis rate decreased as indicated by flow cytometry experiments (both P < 0.05). Wound healing assays revealed that transfection of FOXA2 siRNA promoted ESC migration. Moreover, real-time PCR analysis showed progesterone-induced FOXA2 expression in ESC under physiological conditions. In conclusion, these findings indicate that FOXA2 might be a progesterone-induced gene, which may participate in the 'metastatic' process of eutopic endometrium to ectopic loci in patients with endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometrium Gene Expression Regulation Hepatocyte Nuclear Factor 3-beta Progesterone Case-Control Studies Cell Movement Cell Proliferation Endometriosis Endometrium Endometrium Female Hepatocyte Nuclear Factor 3-beta Humans Primary Cell Culture Progesterone

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