miRNAs Regulation and Its Role as Biomarkers in Endometriosis

Josep Marí-Alexandre, Josep Marí‐Alexandre, Dolors Sánchez-Izquierdo, Juan Gilabert-Estellés, Juan Gilabert–Estellés, Moisés Barceló‐Molina, Moisés Barceló-Molina, Aitana Braza-Boïls, Aitana Braza‐Boïls, Juan Sandoval
International journal of molecular sciences · 2016 · vol. 17(1) , pp. 93 · doi:10.3390/ijms17010093 · PMID:26771608 · W2237304300
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review highlights current knowledge on microRNAs, emphasizing their role in endometriosis and emerging research on their use as biomarkers for the disease.

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Abstract

MicroRNAs (miRNAs) are small non-coding RNAs (18-22 nt) that function as modulators of gene expression. Since their discovery in 1993 in C. elegans, our knowledge about their biogenesis, function, and mechanism of action has increased enormously, especially in recent years, with the development of deep-sequencing technologies. New biogenesis pathways and sources of miRNAs are changing our concept about these molecules. The study of the miRNA contribution to pathological states is a field of great interest in research. Different groups have reported the implication of miRNAs in pathologies such as cancer, diabetes, cardiovascular, and gynecological diseases. It is also well-known that miRNAs are present in biofluids (plasma, serum, urine, semen, and menstrual blood) and have been proposed as ideal candidates as disease biomarkers. The goal of this review is to highlight the current knowledge in the field of miRNAs with a special emphasis to their role in endometriosis and the newest investigations addressing the use of miRNAs as biomarkers for this gynecological disease.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Gene Expression Regulation MicroRNAs Biomarkers Biomarkers Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Humans MicroRNAs MicroRNAs RNA, Messenger RNA, Messenger RNA, Messenger RNA, Small Cytoplasmic

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (36)

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