MicroRNA-Regulated Pathways Associated with Endometriosis

E Maria C Ohlsson Teague, Edward Teague, Kylie H Van der Hoek, Mark B Van der Hoek, Naomi Perry, Prabhath Wagaarachchi, Prabhath T. Wagaarachchi, Sarah A Robertson, Cristin G Print, M. Louise Hull, Louise M Hull
Molecular endocrinology (Baltimore, Md.) · 2008 · vol. 23(2) , pp. 265–275 · doi:10.1210/me.2008-0387 · PMID:19074548 · PMC5419313 · W1993162436
article OA: bronze CC0 ⤵ 201 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study identified 22 differentially expressed microRNAs in ectopic versus eutopic endometrial tissues and found their predicted mRNA targets are involved in pathways previously associated with endometriosis development.

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Abstract

Endometriosis is a prevalent gynecological disease characterized by growth of endometriotic tissue outside the uterine cavity. MicroRNAs (miRNAs) are naturally occurring posttranscriptional regulatory molecules that potentially play a role in endometriotic lesion development. We assessed miRNA expression by microarray analysis in paired ectopic and eutopic endometrial tissues and identified 14 up-regulated (miR-145, miR-143, miR-99a, miR-99b, miR-126, miR-100, miR-125b, miR-150, miR-125a, miR-223, miR-194, miR-365, miR-29c and miR-1) and eight down-regulated (miR-200a, miR-141, miR-200b, miR-142-3p, miR-424, miR-34c, miR-20a and miR-196b) miRNAs. The differential expression of six miRNAs was confirmed by quantitative RT-PCR. An in silico analysis identified 3851 mRNA transcripts as putative targets of the 22 miRNAs. Of these predicted targets, 673 were also differentially expressed in ectopic vs. eutopic endometrial tissue, as determined by microarray. Functional analysis suggested that the 673 miRNA targets constitute molecular pathways previously associated with endometriosis, including c-Jun, CREB-binding protein, protein kinase B (Akt), and cyclin D1 (CCND1) signaling. These pathways appeared to be regulated both transcriptionally as well as by miRNAs at posttranscriptional level. These data are a rich and novel resource for endometriosis and miRNA research and suggest that the 22 miRNAs and their cognate mRNA target sequences constitute pathways that promote endometriosis. Accordingly, miRNAs are potential therapeutic targets for treating this disease.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Gene Expression Regulation MicroRNAs Signal Transduction Female Gene Expression Profiling Humans JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases JNK Mitogen-Activated Protein Kinases MicroRNAs MicroRNAs Molecular Sequence Data Multigene Family Oligonucleotide Array Sequence Analysis Signal Transduction

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