Role of microRNAs in embryo–endometrial interactions: biological functions and clinical applications

Shiwen Qi, Suranga P. Kodithuwakku, Ronald T.K. Pang, Philip C.N. Chiu, Mary H.Y. Tang, Ckf Lee
In: Reproductive and Developmental Medicine · 2023 · vol. 7(4) , pp. 238–251 · doi:10.1097/rd9.0000000000000073 · W4380537424
article OA: diamond CC0
🔓 Open OA copy View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Endometrial and embryo-derived microRNAs regulate maternal-embryo communication and their aberrant expression is linked to pregnancy disorders, making them potential diagnostic biomarkers.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

The human endometrium and embryo both produce microRNAs (miRNAs), which are involved in various physiological activities. Accumulating evident suggested that endometrial miRNAs are regulated by steroid hormones that modulate endometrial functions, whereas embryo-derived miRNAs play vital roles in maternal–embryo communication. The aberrant expression of endometrium- or embryo-derived miRNAs can cause early pregnancy and gestational disorders, including repeated implantation failure, recurrent miscarriage, and pathological conditions such as endometriosis. miRNAs are, therefore, ideal candidates for conducting clinicopathological tests. Potential diagnostic and prognostic tests using miRNAs are under development; however, the therapeutic applications of miRNAs in regulating gestational disorders require further investigation.

My notes (saved in your browser only)

Condition tags

endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Source provenance

openalex
last seen: 2026-06-04T00:00:01.174412+00:00
License: CC0 · commercial use OK