New Therapeutics in Endometriosis: A Review of Hormonal, Non-Hormonal, and Non-Coding RNA Treatments

Géraldine Brichant, Geraldine Brichant, Ines Laraki, Inès Laraki, Laurie Henry, Carine Munaut, Michelle Nisolle
International journal of molecular sciences · 2021 · vol. 22(19) , pp. 10498 · doi:10.3390/ijms221910498 · PMID:34638843 · W3203653962
review OA: gold CC0 ⤵ 69 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review summarizes emerging hormonal, non-hormonal, and non-coding RNA therapeutics under investigation for treating endometriosis by targeting its cellular and molecular mechanisms.

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Abstract

Endometriosis is defined as endometrial-like tissue outside the uterine cavity. It is a chronic inflammatory estrogen-dependent disease causing pain and infertility in about 10% of women of reproductive age. Treatment nowadays consists of medical and surgical therapies. Medical treatments are based on painkillers and hormonal treatments. To date, none of the medical treatments have been able to cure the disease and symptoms recur as soon as the medication is stopped. The development of new biomedical targets, aiming at the cellular and molecular mechanisms responsible for endometriosis, is needed. This article summarizes the most recent medications under investigation in endometriosis treatment with an emphasis on non-coding RNAs that are emerging as key players in several human diseases, including cancer and endometriosis.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Drug Delivery Systems Endometriosis Endometriosis Endometriosis Endometriosis RNA, Untranslated Animals Female Humans RNA, Untranslated

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (100)

Cited by (50)

Source provenance

europepmc
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openalex
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pubmed
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License: CC0 · commercial use OK