Steroids receptors immunohistochemical expression in different sites of endometriosis

Claudia Massarotti, Ilaria Mirabelli Badenier, Mirabelli Badenier I, Michele Paudice, Paudice M, Giulia Scaglione, Valentino Remorgida, Valerio Gaetano Vellone
Journal of gynecology obstetrics and human reproduction · 2020 · vol. 50(3) , pp. 101861 · doi:10.1016/j.jogoh.2020.101861 · PMID:32652301 · W3041295416
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This study investigated the immunohistochemical expression of steroid receptors in endometriotic lesions from different anatomical locations.

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Abstract

BackgroundA better characterization of steroid intracrine pathways in endometriosis lesions may lead to a better understanding of the pathogenesis of the disease and insights on the mechanism of resistance to medical therapy. The study aims to evaluate the expression of steroid receptors in endometriosis lesions, including for the first-time androgen receptors, both in glandular and stromal tissue, and to describe the differences, in any, in receptor expression in the different subtypes.Basic proceduresThis is a retrospective analysis of 76 specimens from 51 women, that underwent laparoscopic surgery for endometriosis at a tertiary hospital between 2015 and 2019. Immunohistochemical detections of estrogen, progesterone and androgen receptors positive cells was performed and the results described in terms of both density and intensity. The density and intensity scores were combined to obtain a final Histological Score (HS). Non-parametric Kruskal-Wallis test or Mann-Whitney U-test were used to compare continuous data, chi square test for categorical data.Main findingsEstrogen receptor α expression was moderate/high in almost all specimens, regardless of the site. Samples from endometriomas presented lower progesterone receptor expression in the epithelium, compared to pelvic sites. Androgen receptor density was higher in stromal cells compared to epithelial cells and in pelvic sites compared to ovarian ones.ConclusionsThe roles of nuclear receptors in endometriosis, including differences in their expression, could help in defining the pathogenesis of the disease and in explaining different responsivity to therapies. The intracrine regulation of steroids plays a relevant role in the metabolic and inflammatory pathogenetic paths of endometriosis: if better understood, its manipulation could be a relevant therapeutic target for treatment.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Receptors, Androgen Receptors, Estrogen Receptors, Progesterone Adult Endometriosis Endometriosis Estrogen Receptor alpha Estrogen Receptor alpha Female Humans Immunohistochemistry Laparoscopy Ovarian Diseases Ovarian Diseases Ovarian Diseases Receptors, Androgen Receptors, Estrogen Receptors, Progesterone

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (19)

Cited by (8)

SciLite annotations

chemicals 4
steroid estrogen progesterone steroid

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