Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms

Xu Wang, Jing Zhang, Xiaojing Liu, Bing Wei, Lei Zhan
Journal of cellular physiology · 2020 · vol. 236(1) , pp. 6–14 · doi:10.1002/jcp.29847 · PMID:32506425 · W3034082461
review OA: closed CC0 ⤵ 15 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This review examines aberrant long noncoding RNA expression in endometriosis, details their molecular mechanisms, and discusses their potential as biomarkers for the disease.

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Abstract

Endometriosis refers to a benign chronic gynecological disorder, and is defined as the ectopic growth of endometrium in pelvic cavity. Endometriosis affects about 10% of reproductive-aged women. Unfortunately, the pathogenesis of endometriosis remains obscure, and the disease witnesses a lack of effective therapy approaches. Therefore, more research needs to be performed to throw light on endometriosis, its pathogenesis, and therapy. Long noncoding RNAs (lncRNAs), which are defined as functional cellular RNA longer than 200 nucleotides, have been implicated in many chronic disorders. It has been suggested that lncRNAs are closely related to the endometriosis process. Nevertheless, the molecular mechanisms by which lncRNAs associate with endometriosis should be elucidated more detailed. In our brief review, we first exhibit the aberrant lncRNAs expression in endometriosis. Then, we talk about the molecular mechanisms underlying lncRNAs in endometriosis. Finally, we also present the potential of lncRNAs as biomarkers for endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis RNA, Long Noncoding Animals Biomarkers Biomarkers Endometriosis Endometriosis Endometrium Endometrium Endometrium Female Gene Expression Gene Expression Humans RNA, Long Noncoding

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (82)

Cited by (15)

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License: CC0 · commercial use OK