A review of the effects of estrogen and epithelial-mesenchymal transformation on intrauterine adhesion and endometriosis

He-Yu Liu; Heyu Liu; Zheng-yan Zhu; Xue-Mei Chen; Xuemei Chen; Jing-quan Lu; Yu Song; Wei Xia

doi:10.1016/j.trim.2022.101679

A review of the effects of estrogen and epithelial-mesenchymal transformation on intrauterine adhesion and endometriosis

He-Yu Liu, Heyu Liu, Zheng-yan Zhu, Xue-Mei Chen, Xuemei Chen, Jing-quan Lu, Yu Song, Wei Xia

Transplant immunology · 2022 · vol. 79 , pp. 101679 · doi:10.1016/j.trim.2022.101679 · PMID:35908631 · W4288459171

review OA: closed CC0 ⤵ 4 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review examines how estrogen and epithelial-mesenchymal transition influence intrauterine adhesion and endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Endometrium Epithelial-Mesenchymal Transition

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References (97)

Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis† via openalex
Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex
Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway via openalex
Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway via openalex
Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation <i>via</i> Wnt/β-catenin Pathway in Endometriosis via openalex
Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway via openalex
Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis via openalex
Endometrial epithelial–mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia via openalex
Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation via openalex
Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function via openalex
Estrogen attenuates TGF-β1-induced EMT in intrauterine adhesion by activating Wnt/β-catenin signaling pathway via openalex
E<sub>2</sub>‐mediated EMT by activation of β‐catenin/Snail signalling during the development of ovarian endometriosis via openalex
Genomic Function of Estrogen Receptor β in Endometriosis via openalex
Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex
Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors via openalex
Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis via openalex
Long non‐coding RNA AFAP1‐AS1 promoting epithelial‐mesenchymal transition of endometriosis is correlated with transcription factor ZEB1 via openalex
Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms via openalex
Melatonin inhibits 17β-estradiol-induced migration, invasion and epithelial-mesenchymal transition in normal and endometriotic endometrial epithelial cells via openalex
MiR-182 inhibits proliferation, migration, invasion and inflammation of endometrial stromal cells through deactivation of NF-κB signaling pathway in endometriosis via openalex
MiR-199a-5p Targets ZEB1 to Inhibit the Epithelial-Mesenchymal Transition of Ovarian Ectopic Endometrial Stromal Cells Via PI3K/Akt/mTOR Signal Pathway In Vitro and In Vivo via openalex
miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo via openalex
MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways via openalex
Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex
Oestrogen induces epithelial‐mesenchymal transition in endometriosis via circ_0004712/miR‐148a‐3p sponge function via openalex
Oestrogen receptors and hypoxia inducible factor 1 alpha expression in abdominal wall endometriosis via openalex
Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex
Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis via openalex
Purinergic Signaling in Endometriosis-Associated Pain via openalex
RETRACTED ARTICLE: miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1 via openalex
RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis via openalex
Ten-Eleven Translocation Genes are Downregulated in Endometriosis via openalex
Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17&beta;-estradiol on endometrial regeneration for intrauterine adhesions in a rat model via openalex
Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis via openalex
Villainous role of estrogen in macrophage-nerve interaction in endometriosis via openalex
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Cited by (4)

Source provenance

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openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-29T00:34:33.406613+00:00
unpaywall: last seen: 2026-06-02T02:00:03.124865+00:00

License: CC0 · commercial use OK

[1] Autophagy contributes to hypoxia-induced epithelial to mesenchymal transition of endometrial epithelial cells in endometriosis† via openalex

[2] Cellular Changes Consistent With Epithelial–Mesenchymal Transition and Fibroblast-to-Myofibroblast Transdifferentiation in the Progression of Experimental Endometriosis in Baboons via openalex

[3] Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway via openalex

[4] Circular RNA PIP5K1A (circPIP5K1A) accelerates endometriosis progression by regulating the miR-153-3p/Thymosin Beta-4 X-Linked (TMSB4X) pathway via openalex

[5] Combination of Ferulic Acid, Ligustrazine and Tetrahydropalmatine attenuates Epithelial-mesenchymal Transformation <i>via</i> Wnt/β-catenin Pathway in Endometriosis via openalex

[6] Downregulated circular RNA hsa_circ_0067301 regulates epithelial-mesenchymal transition in endometriosis via the miR-141/Notch signaling pathway via openalex

[7] Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis via openalex

[8] Endometrial epithelial–mesenchymal transition (EMT) by menstruation-related inflammatory factors during hypoxia via openalex

[9] Endometriosis-Derived Stromal Cells Secrete Thrombin and Thromboxane A2, Inducing Platelet Activation via openalex

[10] Estradiol promotes EMT in endometriosis via MALAT1/miR200s sponge function via openalex

[11] Estrogen attenuates TGF-β1-induced EMT in intrauterine adhesion by activating Wnt/β-catenin signaling pathway via openalex

[12] E<sub>2</sub>‐mediated EMT by activation of β‐catenin/Snail signalling during the development of ovarian endometriosis via openalex

[13] Genomic Function of Estrogen Receptor β in Endometriosis via openalex

[14] Hypoxia‐inhibited dual‐specificity phosphatase‐2 expression in endometriotic cells regulates cyclooxygenase‐2 expression via openalex

[15] Knockdown hsa_circ_0063526 inhibits endometriosis progression via regulating the miR-141-5p / EMT axis and downregulating estrogen receptors via openalex

[16] Lipoxin A4 Suppresses Estrogen-Induced Epithelial-Mesenchymal Transition via ALXR-Dependent Manner in Endometriosis via openalex

[17] Long non‐coding RNA AFAP1‐AS1 promoting epithelial‐mesenchymal transition of endometriosis is correlated with transcription factor ZEB1 via openalex

[18] Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms via openalex

[19] Melatonin inhibits 17β-estradiol-induced migration, invasion and epithelial-mesenchymal transition in normal and endometriotic endometrial epithelial cells via openalex

[20] MiR-182 inhibits proliferation, migration, invasion and inflammation of endometrial stromal cells through deactivation of NF-κB signaling pathway in endometriosis via openalex

[21] MiR-199a-5p Targets ZEB1 to Inhibit the Epithelial-Mesenchymal Transition of Ovarian Ectopic Endometrial Stromal Cells Via PI3K/Akt/mTOR Signal Pathway In Vitro and In Vivo via openalex

[22] miR-200c suppresses endometriosis by targeting MALAT1 in vitro and in vivo via openalex

[23] MiR-543 Inhibits the Migration and Epithelial-To-Mesenchymal Transition of TGF-β-Treated Endometrial Stromal Cells via the MAPK and Wnt/β-Catenin Signaling Pathways via openalex

[24] Neuropeptides Substance P and Calcitonin Gene Related Peptide Accelerate the Development and Fibrogenesis of Endometriosis via openalex

[25] Oestrogen induces epithelial‐mesenchymal transition in endometriosis via circ_0004712/miR‐148a‐3p sponge function via openalex

[26] Oestrogen receptors and hypoxia inducible factor 1 alpha expression in abdominal wall endometriosis via openalex

[27] Platelets drive smooth muscle metaplasia and fibrogenesis in endometriosis through epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation via openalex

[28] Progressive development of endometriosis and its hindrance by anti-platelet treatment in mice with induced endometriosis via openalex

[29] Purinergic Signaling in Endometriosis-Associated Pain via openalex

[30] RETRACTED ARTICLE: miR-96-5p regulated TGF-β/SMAD signaling pathway and suppressed endometrial cell viability and migration via targeting TGFBR1 via openalex

[31] RhoA/ROCK pathway mediates the effect of oestrogen on regulating epithelial‐mesenchymal transition and proliferation in endometriosis via openalex

[32] Ten-Eleven Translocation Genes are Downregulated in Endometriosis via openalex

[33] Three-dimensional structure micelles of heparin-poloxamer improve the therapeutic effect of 17&beta;-estradiol on endometrial regeneration for intrauterine adhesions in a rat model via openalex

[34] Upregulation of the long noncoding RNA UBOX5 antisense RNA 1 (UBOX5-AS1) under hypoxic conditions promotes epithelial-mesenchymal transition in endometriosis via openalex

[35] Villainous role of estrogen in macrophage-nerve interaction in endometriosis via openalex

[36] W3004959281 via openalex

[37] W3016339115 via openalex

[38] W3021503750 via openalex

[39] W3027510039 via openalex

[40] W3034795089 via openalex

[41] W3045550416 via openalex

[42] W3084102132 via openalex

[43] W3105326944 via openalex

[44] W3108953374 via openalex

[45] W3124380630 via openalex

[46] W3134886657 via openalex

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[49] W3173233941 via openalex

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[51] W3208055933 via openalex

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