Circular RNA circZFPM2 promotes epithelial-mesenchymal transition in endometriosis by regulating miR-205-5p/ZEB1 signalling pathway

Dandan Wang, Wang D, Cui L, Liangyi Cui, Yang Q, Qing Yang, Wang J, Jiao Wang
Cellular signalling · 2021 · vol. 87 , pp. 110145 · doi:10.1016/j.cellsig.2021.110145 · PMID:34517087 · W3199558176
article OA: closed CC0 ⤵ 11 in-corpus citations
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Circular RNA circZFPM2 enhances epithelial-mesenchymal transition in endometriosis by controlling the miR-205-5p/ZEB1 signaling pathway.

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Abstract

Endometriosis is a debilitating gynecological disease affecting millions of women worldwide, but its exact pathogenesis remains unclear. Circular RNAs (circRNAs) have been demonstrated to be important regulators in multiple diseases. Nonetheless, the potential regulatory mechanism of aberrant circRNA expression in endometriosis has been elusive. The up-regulated circZFPM2 in ectopic endometrial tissues was previously screened by circRNA high-throughput sequencing and was furtherly validated by quantitative real time reverse transcriptase polymerase chain reaction (RT-qPCR). Overexpression of circZFPM2 promoted the proliferation, migration, invasion, and epithelial-mesenchymal transition (EMT) in Ishikawa and End1/E6E7 cells, whereas silencing circZFPM2 produced the opposite effect. Luciferase reporter assays validated that circZFPM2 could directly target miR-205-5p and miR-205-5p target ZEB1. RT-qPCR results showed that miR-205-5p was underexpressed while ZEB1 was overexpressed in ectopic endometrial tissues compared with their expression in eutopic endometria and non-endometriosis control endometria. The expression level of miR-205-5p was inversely proportional and that of ZEB1 was directly proportional with the proliferative, migrative, and invasive ability of endometrial cells. Further in vitro investigation indicated that miR-205-5p could inhibit EMT by targeting ZEB1. Subsequent rescue experiments confirmed that circZFPM2 could induce EMT and promote cell proliferation, migration, and invasion cascades through the miR-205-5p /ZEB1 signaling pathway. Conclusively, circZFPM2 may present a promising biomarker in the diagnosis and treatment of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis MicroRNAs MicroRNAs MicroRNAs RNA, Circular RNA, Circular Cell Movement Cell Movement Cell Proliferation Cell Proliferation Epithelial-Mesenchymal Transition Epithelial-Mesenchymal Transition Female Humans Signal Transduction Zinc Finger E-box-Binding Homeobox 1 Zinc Finger E-box-Binding Homeobox 1 Zinc Finger E-box-Binding Homeobox 1

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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