Comprehensive analysis of circRNA-miRNA-mRNA regulatory network and novel potential biomarkers in eutopic endometrium of adenomyosis

Guo Z, Zhengchen Guo, Lin Q, Qi Lin, Chang Y, Yanan Chang, An Y, Yuanyuan An, Hua Duan, Duan H
Genomics · 2024 · vol. 116(5) , pp. 110877 · doi:10.1016/j.ygeno.2024.110877 · PMID:38852876 · W4399423515
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This study established a circRNA-miRNA-mRNA network in adenomyosis endometrium, identifying hsa_circ_0008959 and SLC15A4 as downregulated and hsa-miR-124-3p as upregulated, with their combination showing diagnostic value.

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Abstract

Adenomyosis (ADS) is a common gynecological disorder, and its pathogenesis remains unclear. This study explores the functions of circRNAs in the eutopic endometrium of ADS and their diagnostic efficacy for ADS. High-throughput RNA sequencing was performed on 12 eutopic endometrial samples from ADS patients and 3 control endometrial samples. Additionally, circRNAs were analyzed in conjunction with clinical features. A competitive endogenous RNA network was established based on bioinformatics analysis, comprising 3 circRNAs, 1 miRNA, and 13 mRNAs. In the ADS group, the expression levels of hsa_circ_0008959 and SLC15A4 were significantly reduced, while hsa-miR-124-3p expression was increased. SLC15A4 was associated with cell proliferation and invasion. Decreased expression of hsa_circ_0008959 and SLC15A4, along with high VAS scores and elevated hsa-miR-124-3p levels, were identified as risk factors for ADS development. The combination of hsa_circ_0008959 and VAS scores demonstrated the highest diagnostic value for ADS.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis Adenomyosis

Funding

funders
[{'doi': '10.13039/501100019871', 'name': 'Capital Medical University Beijing Obstetrics and Gynecology Hospital', 'awards': ['FCYY201920']}, {'doi': '10.13039/501100002799', 'name': 'Capital Medical University', 'awards': []}, {'doi': '10.13039/501100001809', 'name': 'National Natural Science Foundation of China', 'awards': ['81571412']}]

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References (91)

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