Long non‐coding RNA LINC00261 inhibits cell growth and migration in endometriosis
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Abstract
AIM: A previous study reported that LINC00261 is significantly downregulated in human ectopic endometrial tissues. The present study aimed to explore whether LINC00261 is functional in endometriosis cell proliferation, apoptosis and migration. METHODS: By transfecting human endometriosis cell line CRL-7566 with plasmids containing LINC00261, we successfully established the cell CRL-7566/LINC00261 with a high LINC00261 expression level. Cell-counting kit-8 and colony formation assays were conducted to evaluate the effect of LINC00261 on cell proliferation, and flow cytometry analysis and transwell migration assay were conducted to evaluate its effect on cell apoptosis and cell migration, respectively. RESULTS: Cell-counting kit-8 and colony formation assays both indicated that LINC00261 could inhibit cell proliferation in CRL-7566. Flow cytometry analysis confirmed that LINC00261 mediated inhibition of cell proliferation, which might be a consequence of inducting apoptosis. Furthermore, transwell migration assay indicated that LINC00261 could inhibit cell migration in endometriosis. CONCLUSION: LncRNA LINC00261 is capable of inhibiting cell growth and migration in endometriosis.
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Cited by (19)
- Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis 2023
- LncRNA IGF2-AS promotes endometriosis progression through targeting miR-370-3p/IGF2 axis and activating PI3K/AKT/mTOR signaling pathway 2022
- Long non‑coding RNA LINC01960‑201 hinders decidualization of endometrial stromal cell in endometriosis: Relevance to endometrial receptivity 2022
- Exosomal lncRNA HOTAIR Promotes the Progression and Angiogenesis of Endometriosis via the miR-761/HDAC1 Axis and Activation of STAT3-Mediated Inflammation 2022
- Exosomal lncRNA HOTAIR Promotes the Progression and Angiogenesis of Endometriosis via the miR-761/HDAC1 Axis and Activation of STAT3-Mediated Inflammation 2022
- Identification of Functional lncRNAs Associated With Ovarian Endometriosis Based on a ceRNA Network 2021
- Extracellular vesicle-derived long non-coding RNA as circulating biomarkers for endometriosis 2021
- The value of long noncoding RNAs for predicting the recurrence of endometriosis 2021
- <scp>LncRNA AFAP1‐AS1</scp> regulates proliferation and apoptosis of endometriosis through activating <scp>STAT3</scp>/<scp>TGF</scp>‐β/Smad signaling via <scp>miR</scp>‐424‐5p 2021
- Upregulated microRNA let-7a accelerates apoptosis and inhibits proliferation in uterine junctional zone smooth muscle cells in adenomyosis under conditions of a normal activated hippo-YAP1 axis 2021
- LINC01541 Functions as a ceRNA to Modulate the Wnt/β-Catenin Pathway by Decoying miR-506-5p in Endometriosis 2020
- Long noncoding RNAs in endometriosis: Biological functions, expressions, and mechanisms 2020
- Establishment of endometriotic models: the past and future 2020
- Role of Non-coding RNAs in the Pathogenesis of Endometriosis 2020
- Endometriosis-Related ceRNA Network to Identify Predictive Biomarkers of Endometrial Receptivity 2019
- lncRNA/mRNA profiling of endometriosis rat uterine tissues during the implantation window 2019
- LINC01541 overexpression attenuates the 17β-Estradiol-induced migration and invasion capabilities of endometrial stromal cells 2019
- Progress in understanding the relationship between long noncoding RNA and endometriosis 2019
- LINC00261 functions as a competing endogenous RNA to regulate BCL2L11 expression by sponging miR-132-3p in endometriosis. 2019
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- europepmc
- last seen: 2026-06-04T01:30:01.192114+00:00
- openalex
- last seen: 2026-06-04T00:00:01.174412+00:00
- pubmed
- last seen: 2026-05-13T22:20:19.560968+00:00
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