Combined proteomics and transcriptomics identifies serpin family C member 1 associated protein as a biomarker of endometriosis

Xiao-Yan Li, Xiaoyan Li, Xi Wang, Zhiyue Gu, Zhi-Yue Gu, Ting-Ting Sun, Tingting Sun, Jinhua Leng, Jin-Hua Leng, Qi Yu
Annals of medicine · 2023 · vol. 55(2) , pp. 2243825 · doi:10.1080/07853890.2023.2243825 · PMID:37572646 · PMC10424617 · W4385777932
article OA: gold CC0 ⤵ 4 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Proteomics and transcriptomics analysis identified down-regulated fetuin B and serpin family C member 1 as potential endometriosis biomarkers, with SERPINC1 showing significant variance.

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Abstract

OBJECTIVE: To explore potential biomarkers indicating endometriosis (EM). MATERIALS AND METHODS: A proteomics method and combined quantitative transcriptomics were adopted to highlight markers in the EM. Venn analysis was used to integrate the ribonucleic acid sequencing (RNA-seq) and protein profiles. Promising candidate markers were tested by enzyme-related immunosorbent assay. RESULTS: A sum of 979 mRNAs and 39 proteins were tested to be significantly differentially expression in the standard cluster compared with the EM cluster. Venn analysis showed a filtered signature of only two down-regulated molecules in the EM group, i.e. fetuin B (FETUB) and serpin family C member 1 (SERPINC1); the latter showed a big variance between the control category and the EM set in the authentication test. CONCLUSION: SERPINC1 may be a useful possible biomarker for the analysis of EM.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Serpins Serpins Serpins Serpins

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