The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis

Andrei M Malutan, Andrei Mihai Măluţan, Cristina Drugan, Tudor Drugan, Razvan Ciortea, Răzvan Ciortea, Dan Mihu
Central-European journal of immunology · 2016 · vol. 41(2) , pp. 176–181 · doi:10.5114/ceji.2016.60992 · PMID:27536203 · PMC4967651 · W2505370798
article OA: gold CC0 ⤵ 9 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

Interleukin-4 serum levels were significantly higher in women with advanced endometriosis compared to controls, but the IL-4 -590C/T genetic polymorphism was not associated with the disease.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This case-control study measured IL-4 serum levels and IL-4 promoter -590C/T genetic polymorphism in 80 women with surgically confirmed advanced endometriosis (rASRM stage III/IV) and 85 healthy fertile controls using Luminex for cytokines and PCR-RFLP for genotyping. IL-4 serum levels were significantly higher in the endometriosis group than in controls (138.459 vs 84.710 pg/ml, p < 0.001), while IL-4 levels did not differ by IL-4 -590C/T genotype. There were no significant differences in IL-4 -590C/T genotype frequencies or allele frequencies between patients and controls (reported χ2 statistics with odds ratio 1.3636, 95% CI 0.725–2.564). This paper centrally about endometriosis — it examines whether increased IL-4 serum levels and the IL-4 -590C/T promoter polymorphism are associated with advanced endometriosis.

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Abstract

AIM OF THE STUDY: Aim of the study was to investigate interleukin (IL)-4 serum levels in patients with advanced endometriosis and whether IL-4 promoter region (-590C/T) genetic polymorphism is involved in genetic susceptibility to endometriosis. MATERIAL AND METHODS: IL-4 serum levels and IL-4 -590C/T genetic polymorphism were determined for 80 patients with advanced endometriosis and 85 healthy fertile women using a multiplex cytokine kit, with a Luminex 200 system; high molecular weight genomic DNA was extracted from peripheral blood leukocytes, and further analyzed by PCR amplification and restriction fragment length polymorphism (PCR-PFLP). The relationship between IL-4 serum levels, genotypes and haplotypes and the presence of endometriosis was explored. RESULTS: Interleukin 4 serum levels were significantly higher in the endometriosis group compared to controls (138,459 compared to 84,710, p < 0.001). No significant difference was observed in IL-4 serum levels between genotypes. There were no differences in IL-4 -590C/T genotypes and allele frequencies between control women and patients with endometriosis (χ (2) = 0.496, and χ (2) = 0.928, OR = 1.3636, CI: 0.725-2.564). CONCLUSIONS: The results suggest that in patients with advanced stages of endometriosis there is a higher serum level of IL-4, and that this value, or the presence of the disease, is not influenced by the presence of IL-4 -590C/T genetic polymorphism.

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endometriosis

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