Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis

Shulin Zhong; Yuzhen Liang; Zhixi Wu; Li Wei; Wei Li

doi:10.1016/j.jri.2023.103969

Association between polymorphisms of cytokine genes and endometriosis: A comprehensive systematic review and meta-analysis

Shulin Zhong, Yuzhen Liang, Zhixi Wu, Li Wei, Wei Li

Journal of reproductive immunology · 2023 · vol. 158 , pp. 103969 · doi:10.1016/j.jri.2023.103969 · PMID:37295065 · W4378189099

review OA: closed CC0 ⤵ 5 in-corpus citations

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⚙ AI-generated summary by claude@2026-06, 2026-06-07 ⓘ

This meta-analysis reviewed studies investigating the association between cytokine gene polymorphisms and endometriosis, synthesizing findings to identify potential genetic links.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10 Interleukin-10

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (81)

A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis via openalex
Anti-inflammatory cytokines in endometriosis via openalex
Association between interleukin-10 promoter polymorphisms and endometriosis: A meta-analysis via openalex
Association of Interleukin-10 Promoter Polymorphism and Endometriosis via openalex
Association of interleukin 1beta gene (+3953) polymorphism and severity of endometriosis in Turkish women via openalex
Association of tumor necrosis factor- gene polymorphisms with advanced stage endometriosis via openalex
Association study of the<i>TNF-α</i>−1031T/C and<i>VEGF</i> + 450G/C polymorphisms with susceptibility to endometriosis via openalex
Classification of endometriosis via openalex
Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis. via openalex
Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options via openalex
Endometriosis: Polymorphisms for Interleukin-1β (IL-1β)-511 Promoter, IL-1β Exon 5, and IL-1 Receptor Antagonist: Nonassociation with Endometriosis via openalex
Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. via openalex
Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis via openalex
Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target via openalex
Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis via openalex
Interferon- gene dinucleotide (CA) repeat and interleukin-4 promoter region (-590C/T) polymorphisms in Japanese patients with endometriosis via openalex
Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis via openalex
Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis via openalex
New biomarkers in endometriosis via openalex
ORIGINAL ARTICLE: Tumor Necrosis Factor (TNF)–TNF Receptor Gene Polymorphisms and Their Serum Levels in Korean Women with Endometriosis via openalex
Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis via openalex
Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex
Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women via openalex
Polymorphisms of TNF-alpha (− 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study via openalex
Prevalence and Polymorphism in Interferon-γ Gene (CA) Repeats with Different Stages of Endometriosis via openalex
Regulated on Activation, Normal T-Cell-Expressed and -Secreted mRNA Expression in Normal Endometrium and Endometriotic Implants via openalex
Rethinking mechanisms, diagnosis and management of endometriosis via openalex
Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis via openalex
Synergistic effect of interleukin‐6 promoter (IL6 −634C/G) and intercellular adhesion molecule‐1 (ICAM‐1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women via openalex
The Association Between Endometriosis and Polymorphisms in the Interleukin‐1 Family Genes in <scp>K</scp>orean Women via openalex
The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis via openalex
The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population. via openalex
The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis via openalex
The endometrial immune environment of women with endometriosis via openalex
The Interleukin-6 –174G/C Promoter Polymorphism Is Not Associated With Endometriosis in South Indian Women via openalex
The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex
The link between immunity, autoimmunity and endometriosis: a literature update via openalex
The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex
The Role of the Immune System in the Development of Endometriosis via openalex
The tumor necrosis factor-α promoter −1031C polymorphism is associated with decreased risk of endometriosis in a Japanese population via openalex
Transforming Growth Factor-β1 Gene Polymorphisms in Korean Women With Endometriosis via openalex
Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis via openalex
Tumor necrosis factor-α and interleukin-6 promoter gene polymorphisms are not associated with an increased risk of endometriosis via openalex
Tumor Necrosis Factor-α Promotor Polymorphisms and Endometriosis via openalex
W6846573796 via openalex
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W4289100839 via openalex
W4313830852 via openalex
W4407292751 via openalex
W6693542539 via openalex
W6715442218 via openalex
W6768257159 via openalex
W6772248476 via openalex
W6777148296 via openalex
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Cited by (5)

Source provenance

europepmc: last seen: 2026-06-04T01:30:01.192114+00:00
openalex: last seen: 2026-06-10T17:14:06.276822+00:00
pubmed: last seen: 2026-05-29T00:33:36.739615+00:00

License: CC0 · commercial use OK

[1] A functional promoter polymorphism in interleukin-10 gene influences susceptibility to endometriosis via openalex

[2] Anti-inflammatory cytokines in endometriosis via openalex

[3] Association between interleukin-10 promoter polymorphisms and endometriosis: A meta-analysis via openalex

[4] Association of Interleukin-10 Promoter Polymorphism and Endometriosis via openalex

[5] Association of interleukin 1beta gene (+3953) polymorphism and severity of endometriosis in Turkish women via openalex

[6] Association of tumor necrosis factor- gene polymorphisms with advanced stage endometriosis via openalex

[7] Association study of the<i>TNF-α</i>−1031T/C and<i>VEGF</i> + 450G/C polymorphisms with susceptibility to endometriosis via openalex

[8] Classification of endometriosis via openalex

[9] Effects of gene polymorphism and serum levels of IL-2 and IL-6 on endometriosis. via openalex

[10] Endometriosis: An Inflammatory Disease That Requires New Therapeutic Options via openalex

[11] Endometriosis: Polymorphisms for Interleukin-1β (IL-1β)-511 Promoter, IL-1β Exon 5, and IL-1 Receptor Antagonist: Nonassociation with Endometriosis via openalex

[12] Evaluation of Tumor Necrosis Factor Alpha Polymorphism Frequencies in Endometriosis. via openalex

[13] Genetic, Epigenetic, and Steroidogenic Modulation Mechanisms in Endometriosis via openalex

[14] Immunological Basis of the Endometriosis: The Complement System as a Potential Therapeutic Target via openalex

[15] Intercellular Adhesion Molecule-1 and Interleukin-6 Gene Polymorphisms in Patients with Advanced-Stage Endometriosis via openalex

[16] Interferon- gene dinucleotide (CA) repeat and interleukin-4 promoter region (-590C/T) polymorphisms in Japanese patients with endometriosis via openalex

[17] Interleukin-10 gene promoter polymorphisms and their protein production in peritoneal fluid in patients with endometriosis via openalex

[18] Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis via openalex

[19] New biomarkers in endometriosis via openalex

[20] ORIGINAL ARTICLE: Tumor Necrosis Factor (TNF)–TNF Receptor Gene Polymorphisms and Their Serum Levels in Korean Women with Endometriosis via openalex

[21] Polymorphism for Interleukin-4 (-590 C/T) Promoter: Non-Association with Endometriosis via openalex

[22] Polymorphism for Transforming Growth Factor Beta 1-509 (TGF-B1-509): Association with Endometriosis via openalex

[23] Polymorphisms of ICAM-1 and IL-6 genes related to endometriosis in a sample of Brazilian women via openalex

[24] Polymorphisms of TNF-alpha (− 308), IL-1beta (+ 3954) and IL1-Ra (VNTR) are associated to severe stage of endometriosis in Mexican women: a case control study via openalex

[25] Prevalence and Polymorphism in Interferon-γ Gene (CA) Repeats with Different Stages of Endometriosis via openalex

[26] Regulated on Activation, Normal T-Cell-Expressed and -Secreted mRNA Expression in Normal Endometrium and Endometriotic Implants via openalex

[27] Rethinking mechanisms, diagnosis and management of endometriosis via openalex

[28] Study of association between promoter tumor necrosing factor alpha gene polymorphisms in -850T/C, -863 A/C, and endometriosis via openalex

[29] Synergistic effect of interleukin‐6 promoter (IL6 −634C/G) and intercellular adhesion molecule‐1 (ICAM‐1 469K/E) gene polymorphisms on the risk of endometriosis in Japanese women via openalex

[30] The Association Between Endometriosis and Polymorphisms in the Interleukin‐1 Family Genes in <scp>K</scp>orean Women via openalex

[31] The association between interleukin-4 -590C/T genetic polymorphism, IL-4 serum level, and advanced endometriosis via openalex

[32] The Association between TNF-alpha Gene Polymorphisms and Endometriosis in An Iranian Population. via openalex

[33] The cytokine profiles in follicular fluid and reproductive outcomes in women with endometriosis via openalex

[34] The endometrial immune environment of women with endometriosis via openalex

[35] The Interleukin-6 –174G/C Promoter Polymorphism Is Not Associated With Endometriosis in South Indian Women via openalex

[36] The involvement of T lymphocytes in the pathogenesis of endometriotic tissues overgrowth in women with endometriosis via openalex

[37] The link between immunity, autoimmunity and endometriosis: a literature update via openalex

[38] The Pathogenesis of Endometriosis: Molecular and Cell Biology Insights via openalex

[39] The Role of the Immune System in the Development of Endometriosis via openalex

[40] The tumor necrosis factor-α promoter −1031C polymorphism is associated with decreased risk of endometriosis in a Japanese population via openalex

[41] Transforming Growth Factor-β1 Gene Polymorphisms in Korean Women With Endometriosis via openalex

[42] Tumor Necrosis Factor and Interleukin‐6 Gene Polymorphisms and Endometriosis Risk in Asians: A Systematic Review and Meta‐Analysis via openalex

[43] Tumor necrosis factor-α and interleukin-6 promoter gene polymorphisms are not associated with an increased risk of endometriosis via openalex

[44] Tumor Necrosis Factor-α Promotor Polymorphisms and Endometriosis via openalex

[45] W6846573796 via openalex

[46] W1993422257 via openalex

[47] W2005245112 via openalex

[48] W2006347567 via openalex

[49] W2019406753 via openalex

[50] W2030963379 via openalex

[51] W2121171258 via openalex

[52] W2161374186 via openalex

[53] W2178575967 via openalex

[54] W2410951435 via openalex

[55] W2563266730 via openalex

[56] W2993083920 via openalex

[57] W2998624350 via openalex

[58] W3093241119 via openalex

[59] W3134885188 via openalex

[60] W3147809641 via openalex

[61] W3158086066 via openalex

[62] W3165294846 via openalex

[63] W3198022227 via openalex

[64] W3199412530 via openalex

[65] W3202184075 via openalex

[66] W4281750162 via openalex

[67] W4283318099 via openalex

[68] W4289100839 via openalex

[69] W4313830852 via openalex

[70] W4407292751 via openalex

[71] W6693542539 via openalex

[72] W6715442218 via openalex

[73] W6768257159 via openalex

[74] W6772248476 via openalex

[75] W6777148296 via openalex

[76] W6777163094 via openalex

[77] W6777963923 via openalex

[78] W6788322831 via openalex

[79] W6793373326 via openalex

[80] W6809451424 via openalex

[81] W6843086562 via openalex