Investigation of TGF-β1 gene variant and expression in a group of Iranian women with endometriosis

Mahdokht Babaei, Negar Sarhangi, Maryam Shahrabi-Farahani, Farshad Sharifi, Majid Alipor, Soheila Aminimoghaddam, Mahsa M. Amoli
Archives of gynecology and obstetrics · 2021 · vol. 304(6) , pp. 1527–1534 · doi:10.1007/s00404-021-06195-4 · PMID:34480227 · W3197511181
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

This study investigated associations between the TGF-β1 gene variant rs1800469 and endometriosis risk, finding a significant association, but found no difference in TGF-β1 mRNA expression.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-08 ⓘ

This study assessed whether the TGF-β1 gene −509 C/T polymorphism (rs1800469) and TGF-β1 mRNA expression in eutopic endometrium are associated with endometriosis in an Iranian population. The researchers genotyped 100 histologically confirmed endometriosis patients and 197 controls, and measured TGF-β1 mRNA in eutopic endometrial tissue from 15 patients and 15 healthy controls using real-time PCR, including evaluation across the menstrual cycle. They found significant associations between rs1800469 allele and genotype frequencies and endometriosis risk, but no significant differences in TGF-β1 mRNA expression between cases and controls, nor differences across the menstrual cycle. The paper explicitly concludes that the genetic variant relates to susceptibility, while expression did not, and it does not identify funding support or provide additional limitations beyond the measured expression context. This paper is centrally about endometriosis—specifically, the association of a TGF-β1 rs1800469 genetic variant and eutopic endometrial TGF-β1 mRNA expression with endometriosis risk.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Endometriosis Endometrium Female Humans Iran Menstrual Cycle Transforming Growth Factor beta1 Transforming Growth Factor beta1

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