Transforming Growth Factor β1 Gene Polymorphism —509C/T in Deep Infiltrating Endometriosis

K J A F van Kaam, Andrea Romano, A Romano, G A J Dunselman, Patrick G. Groothuis, P G Groothuis
Reproductive sciences (Thousand Oaks, Calif.) · 2007 · vol. 14(4) , pp. 367–373 · doi:10.1177/1933719107303436 · PMID:17644809 · W1983845231
article OA: closed CC0 ⤵ 13 in-corpus citations
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-07 ⓘ

This study investigated the association between the TGF-β1 gene −509C/T polymorphism and deep infiltrating endometriosis and found no statistically significant difference in frequency between groups.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-07 ⓘ

This study tested whether the TGF-β1 gene −509C/T polymorphism, which could affect biologically active TGF-β1, is associated with deep infiltrating endometriosis by comparing women with deep infiltrating endometriosis (n=72) to gynecologic patients without endometriosis symptoms (n=95) and healthy females (n=93). TGF-β1 −509C/T genotypes were determined using PCR-restriction fragment length polymorphism analysis. The authors found no statistically significant differences in −509C/T polymorphism frequency between the groups, concluding that their results do not support an association between this polymorphism and increased risk of deep infiltrating endometriosis. This paper is centrally about endometriosis — it evaluates whether a specific TGF-β1 genetic polymorphism is linked to deep infiltrating endometriosis risk.

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Condition tags

endometriosisdie_deep_infiltrating

MeSH descriptors

Endometriosis Polymorphism, Single Nucleotide Transforming Growth Factor beta1 Cytosine DNA DNA DNA Endometriosis Endometriosis Endometriosis Endometriosis Female Genotype Humans Polymerase Chain Reaction Thymine Transforming Growth Factor beta1

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