Association of estrogen receptor gene polymorphisms with endometriosis

Ioannis Georgiou, I Georgiou, Maria Syrrou, M Syrrou, I Bouba, Ioanna Bouba, N Dalkalitsis, Dalkalitsis N, Paschopoulos M, Minas Paschopoulos, M Paschopoulos, I Navrozoglou, Navrozoglou I, Iordanis Navrozoglou, D Lolis, Dimitrios Lolis, Lolis D
Fertility and Sterility · 1999 · vol. 72(1) , pp. 164–166 · doi:10.1016/s0015-0282(99)00198-3 · PMID:10428168 · W2000251890
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This paper investigates the relationship between variations in the estrogen receptor gene and the occurrence of endometriosis.

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Abstract

ObjectiveTo explore the association of the estrogen receptor two-allele (point) polymorphism and multiallele (microsatellite) polymorphism with endometriosis.DesignCase-control study.SettingGenetics and Endoscopy Unit, Department of Obstetrics and Gynecology, Ioannina University HOSPITAL, Ioannina, Greece.Patient(s)Fifty-seven women with surgically and histologically diagnosed endometriosis of stages I-IV.Intervention(s)Diagnostic laparoscopy.Main outcome measure(s)Frequency and distribution of the estrogen receptor gene polymorphisms.Result(s)There was a statistically significant difference between the patients and the controls in the frequency of the two-allele Pvu II polymorphism (0.72 vs. 0.49) and in the median repeats of the (TA)n multiallele polymorphism (15 vs. 20 repeats). In both groups, linkage was found between the fewer (TA)n repeats (range, 12-19) and the positive Pvu II polymorphism.Conclusion(s)The variability of the estrogen receptor gene likely contributes to the pathogenesis of endometriosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis Polymorphism, Genetic Receptors, Estrogen Adult Alleles Case-Control Studies Endometriosis Female Gene Frequency Genetic Linkage Homozygote Humans Polymorphism, Genetic Receptors, Estrogen Repetitive Sequences, Nucleic Acid

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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Cited by (50)

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