Effect of Soy Isoflavones on Endometriosis

Masaki Tsuchiya, M Tsuchiya, Tsutomu Miura, Tomoyuki Hanaoka, Motoki Iwasaki, Hiroshi Sasaki, Tadao Tanaka, Hiroyuki Nakao, Takahiko Katoh, Tsuyomu Ikenoue, Michinori Kabuto, Shoichiro Tsugane
Epidemiology (Cambridge, Mass.) · 2007 · vol. 18(3) , pp. 402–408 · doi:10.1097/01.ede.0000257571.01358.f9 · PMID:17474167 · W2068753144
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Higher urinary genistein and daidzein levels were associated with a decreased risk of advanced endometriosis, with gene polymorphisms potentially modifying the effect of genistein.

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Abstract

BACKGROUND: Progression of endometriosis is considered estrogen-dependent. Dietary soy isoflavones may affect the risk of endometriosis, and polymorphisms in estrogen receptor genes may modify this association. We examined associations among soy isoflavone intake, estrogen receptor 2 (ESR2) gene polymorphisms and risk of endometriosis. METHODS: We recruited women age 20-45 years old who had consulted a university hospital for infertility in Tokyo, Japan in 1999 or 2000. A total of 138 eligible women were diagnosed laparoscopically and classified into 3 subgroups: control (no endometriosis), early endometriosis (stage I-II) and advanced endometriosis (stage III-IV). We measured urinary levels of genistein and daidzein as markers for dietary intake of soy isoflavones, and genotyped ESR2 gene RsaI polymorphisms. RESULTS: Higher levels of urinary genistein and daidzein were associated with decreased risk of advanced endometriosis (P for trend = 0.01 and 0.06, respectively) but not early endometriosis. For advanced endometriosis, the adjusted odds ratio for the highest quartile group was 0.21 (95% confidence interval = 0.06-0.76) for genistein and 0.29 (0.08-1.03) for daidzein, when compared with the lowest group. Inverse associations were also noted between urinary isoflavones and the severity of endometriosis (P for trend = 0.01 for genistein and 0.07 for daidzein). For advanced endometriosis, ESR2 gene RsaI polymorphism appeared to modify the effects of genistein (P for interaction = 0.03). CONCLUSIONS: Dietary isoflavones may reduce the risk of endometriosis among Japanese women.

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Condition tags

mesh:D004715endometriosisinfertility

MeSH descriptors

Endometriosis Estrogen Receptor beta Glycine max Isoflavones Polymorphism, Genetic Adult Diet Endometriosis Endometriosis Estrogen Receptor beta Female Genistein Genistein Humans Isoflavones Isoflavones Isoflavones Middle Aged Risk

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