Decreased expression of aromatase in the Ishikawa and RL95-2 cells by the isoflavone, puerarin, is associated with inhibition of c-jun expression and AP-1 activity

Chaoqin Yu, Yanwei Li, Huan Chen, Shengsheng Yang, Guangru Xie
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association · 2008 · vol. 46(12) , pp. 3671–3676 · doi:10.1016/j.fct.2008.09.045 · PMID:18848966 · W1987640074
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

Puerarin treatment decreases aromatase expression in Ishikawa and RL95-2 cells, which is linked to reduced c-jun expression and AP-1 activity.

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MeSH descriptors

Aromatase Aromatase Inhibitors Isoflavones Proto-Oncogene Proteins c-jun Transcription Factor AP-1 5' Flanking Region Aromatase Aromatase Blotting, Western Cell Line Down-Regulation Down-Regulation Endometrium Endometrium Endometrium Epithelial Cells Epithelial Cells Estradiol Estradiol Female

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