Exploration of the molecular linkage between endometriosis and Crohn disease by bioinformatics methods

Weijie Zhou, Peizhu Su, Yilin Wang, Zhaotao Li, Liu Liu
Medicine · 2024 · vol. 103(20) , pp. e38097 · doi:10.1097/md.0000000000038097 · PMID:38758892 · PMC11098239 · W4397040110
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study identified 50 common genes between endometriosis and Crohn disease, implicating pathways like MAPK and VEGF, and highlighting FGF9, FZD7, IGFBP5, KDR, and NAMPT as potentially key in their molecular linkage.

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Abstract

BACKGROUND: Endometriosis (EMT) is a common disease in reproductive-age woman and Crohn disease (CD) is a chronic inflammatory disorder in gastrointestinal tract. Previous studies reported that patients with EMT had an increased risk of CD. However, the linkage between EMT and CD remains unclear. In this study, we aimed to investigate the potential molecular mechanism of EMT and CD. METHODS: The microarray data of EMT and CD were downloaded from Gene Expression Omnibus. Common genes of EMT and CD were obtained to perform the Gene Ontology and Kyoto Encyclopedia of Gene Genomes enrichments. The protein-protein interaction network was constructed by Cytoscape software and the hub genes were identified by CytoHubba plug-in. Finally we predicted the transcription factors (TFs) of hub genes and constructed a TFs-hub genes regulation network. RESULTS: A total of 50 common genes were identified. Kyoto Encyclopedia of Gene Genomes enrichment showed that the common genes mainly enriched in MAPK pathway, VEGF pathway, Wnt pathway, TGF-beta pathway, and Ras pathway. Fifteen hub genes were collected from the protein-protein interaction network, including FMOD, FRZB, CPE, SST, ISG15, EFEMP1, KDR, ADRA2A, FZD7, AQP1, IGFBP5, NAMPT, PLUA, FGF9, and FHL2. Among them, FGF9, FZD7, IGFBP5, KDR, and NAMPT were both validated in the other 2 datasets. Finally TFs-hub genes regulation network were constructed. CONCLUSION: Our findings firstly revealed the linkage between EMT and CD, including inflammation, angiogenesis, immune regulation, and cell behaviors, which may lead to the risk of CD in EMT. FGF9, FZD7, IGFBP5, KDR, and NAMPT may closely relate to the linkage.

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Condition tags

endometriosis

MeSH descriptors

Computational Biology Computational Biology Computational Biology Computational Biology Computational Biology Computational Biology Computational Biology Computational Biology Computational Biology Crohn Disease Crohn Disease Crohn Disease Crohn Disease Crohn Disease Crohn Disease Crohn Disease Crohn Disease Crohn Disease Endometriosis Endometriosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (86)

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