Expression and Mitogenic Effect of Fibroblast Growth Factor-9 in Human Endometriotic Implant Is Regulated by Aberrant Production of Estrogen

Lih-Yuh C Wing, Lih‐Yuh C. Wing, Pei-Chin Chuang, Meng‐Hsing Wu, Meng-Hsing Wu, Hsiu-Mei Chen, Hsiu‐Mei Chen, Shaw-Jenq Tsai, Shaw‐Jenq Tsai
The Journal of clinical endocrinology and metabolism · 2003 · vol. 88(11) , pp. 5547–5554 · doi:10.1210/jc.2003-030597 · W2031607357
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Fibroblast growth factor-9 expression in human endometriotic implants is increased by estrogen and contributes to stromal cell proliferation, particularly when peritoneal estrogen levels are high.

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Abstract

Fibroblast growth factor-9 (FGF-9) is a steroid-regulated mitogen and survival factor for nerve and mesenchymal cells. In the current study, we determined the expression pattern and functional roles of FGF-9 in the ectopic endometriotic lesions. We found that FGF-9 and its receptors were effectively expressed by ectopic endometriotic tissues. The expression of FGF-9 was greater in the early stage of endometriosis, compared with the severe stage, which is consistent with concentration of 17 beta-estradiol in the peritoneal fluid of women with endometriosis. In addition, expression of FGF-9 in ectopic endometriotic stromal cell was inhibited by treatment with ICI 182,870 indicating it is likely regulated by estrogen in an autocrine manner. Administration of 17 beta-estradiol induced FGF-9, FGF receptor 2IIIc, and FGF receptor 3IIIc expression in endometriotic stromal cells. Concordant with this result, treatment of endometriotic stromal cells with 4-hydroxyandrostenedione (an aromatase inhibitor) or ICI 182,870 inhibited their proliferation, and that was reversed by coadministration with 17 beta-estradiol or FGF-9. In conclusion, expression of FGF-9 in endometriotic stromal cells is associated with aberrant production of estrogen. The capability of proliferation possessed by endometriotic stromal cell during menstruation when ovarian 17 beta-estradiol is in the nadir may be mediated, at least in part, by autocrined estrogen-stimulated expression of FGF-9 and its receptors.

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Condition tags

mesh:D004715endometriosis

MeSH descriptors

Endometriosis Estradiol Fibroblast Growth Factors Mitogens Cell Division Cell Division Endometrial Neoplasms Endometriosis Endometriosis Estradiol Estradiol Female Fibroblast Growth Factor 9 Fibroblast Growth Factors Fibroblast Growth Factors Fibroblast Growth Factors Gene Expression Gene Expression Humans Menstruation

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