Quantitative analysis of epidermal growth factor receptor gene expression in endometriosis.
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This study found significantly lower epidermal growth factor receptor mRNA levels in endometriotic tissues compared to eutopic endometrium, while protein expression intensity was similar between both.
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Abstract
The molecular mechanisms by which endometriosis persists in locations outside the uterus are unclear. Recently, the epidermal growth factor receptor (EGF-R) has been postulated to have a role in the disease process of endometriosis. To explore this, we determined the levels of EGF-R protein and messenger ribonucleic acid (mRNA) expression in endometriotic tissues and compared the levels to that of eutopic endometrium. Using rabbit anti-EGF-R antibody, we found more intense immunohistochemical staining for EGF-R in glandular cells than in stromal cells of both endometriomas and endometriotic implants. No difference in staining intensity was noted between endometriotic tissues and eutopic endometrium. A ribonuclease protection assay was used to determine mRNA levels for EGF-R. PhosphoImager analysis revealed the following levels of mRNA for EGF-R; eutopic endometrium, 1.00 +/- 0.27 (arbitrary units; mean +/- SEM; n = 6 patients); cyst walls of endometriomas, 0.21 +/- 0.12 (n = 10 patients); endometriotic implants, 0.29 +/- 0.13 (n = 9 patients); and pelvic adhesions, 0.03 +/- 0.03 (n = 5 patients). Endometriotic tissues had significantly less mRNA for EGF-R than eutopic endometrium (P < 0.05, by Newman-Keuls test). Our findings support the hypothesis that EGF-R may be associated with the disease process of endometriosis.
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Cited by (28)
- Proteomic analysis of peritoneal fluid identified COMP and TGFBI as new candidate biomarkers for endometriosis 2021
- microRNA expression analysis in endometriotic serum treated mesenchymal stem cells 2017
- Pain related genes in endometriosis: A meta-analysis 2015
- Roles of Prostaglandin E2 in Endometriosis 2014
- Inhibition of epidermal growth factor receptor restores decidualization markers in stromal fibroblasts from women with endometriosis 2014
- A Novel Role of the Sp/KLF Transcription Factor KLF11 in Arresting Progression of Endometriosis 2013
- Prostaglandin E <sub>2</sub> : the master of endometriosis? 2010
- Expression of the epidermal growth factor receptor family in correlation to the estrogen receptor a expression in peritoneal and ovarian endometriosis 2009
- Expression and role of peptides, proteins and growth factors in the pathogenesis of endometriosis 2009
- Recent advances in molecular genetics of endometriosis 2009
- Expression of the Epidermal Growth Factor System in Eutopic Endometrium from Women with Endometriosis Differs from That in Endometrium from Healthy Women 2008
- Endometriosis: disease pathophysiology and the role of prostaglandins 2007
- Untersuchungen zur Expression und endokrinen Regulation der epidermal growth factor receptor Familie in endometriotischen Läsionen 2007
- Gene expression profiles and functional characterization of human immortalized endometriotic epithelial and stromal cells 2007
- An investigation of the potential malignant characteristics of endometriosis 2005
- Combined inhibition of vascular endothelial growth factor (VEGF), fibroblast growth factor and platelet-derived growth factor, but not inhibition of VEGF alone, effectively suppresses angiogenesis and vessel maturation in endometriotic lesions 2005
- Expression and Mitogenic Effect of Fibroblast Growth Factor-9 in Human Endometriotic Implant Is Regulated by Aberrant Production of Estrogen 2003
- Angiogenic Factors in Endometriosis 2002
- Cytokine Network of Eutopic and Ectopic Endometrium in Women with Adenomyosis 2002
- Angiogenesis in Endometriosis 2001
- Endometrial Anomalies in Women with Endometriosis 2001
- Reduced proliferation and cell adhesion in endometriosis 2000
- Detection of DNA copy number changes in human endometriosis by comparative genomic hybridization 1999
- Lower antigenecity of long-term in vitro cultured eutopic endometrial stromal cells from endometriotic patients: a possible evidence of genetic disorders in endometriosis. 1998
- BASIC RESEARCH IN ENDOMETRIOSIS 1997
- Peritoneal Cellular Immunity and Endometriosis 1997
- Morphologic characteristics of endometriosis in the mouse model: application to toxicology 1997
- Epidermal growth factor and basic fibroblast growth factor in peritoneal fluid of women with endometriosis 1996
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