Lower antigenecity of long-term in vitro cultured eutopic endometrial stromal cells from endometriotic patients: a possible evidence of genetic disorders in endometriosis.
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Long-term in vitro culture of eutopic endometrial stromal cells from endometriosis patients revealed lower expression of seven antigens compared to controls, suggesting potential genetic abnormalities.
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Abstract
In order to investigate an evidence for genetic disorders in endometriotic patients, eutopic endometrial stromal cells were cultured in vitro for more than 4 months and their antigenecities were characterized by flowcytometry. Eutopic stromal cells from 3 endometriotic patients showed lower expressions of the seven antigens (4 cytokine receptors and 3 leukocyte antigens) than the stromal cells from 5 non-endometriotic women. The preliminary results suggest a possibility that endometriotic patients have certain irreversible genetic abnormalities in the stromal cells, and suggest that endometriosis does not occur as a result in vitro unknown transient stimulation.
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Cites (4)
- Interleukin-6 secretion in vitro is up-regulated in ectopic and eutopic endometrial stromal cells from women with endometriosis. 1996
- Epidermal growth factor receptor expression in normal endometrium and endometriosis: an immunohistochemical study 1992
- Quantitative analysis of epidermal growth factor receptor gene expression in endometriosis. 1994
- The actions of estradiol and epidermal growth factor in endometrial and endometriotic stroma in vitro 1994
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