Increased expression of fibroblast growth factor receptor 1 in endometriosis and its correlation with endometriosis-related dysmenorrhea and recurrence

Linjie Zhao, Zhao L, Huiliang Yang, Xuan Y, Xuan Yu, Yu Xuan, Zhongyue Luo, Luo Z, Qiao Lin, Lin Q, Zhao J, Jitong Zhao, Ren N, Ning Ren, Zhou S, Shengtao Zhou, Zhao X, Xia Zhao
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 184 , pp. 117–124 · doi:10.1016/j.ejogrb.2014.11.013 · PMID:25500535 · W2019508711
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This study investigated fibroblast growth factor receptor 1 (FGFR1) expression in endometriosis and found it correlated with dysmenorrhea and disease recurrence.

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Abstract

Objective(s)This study aims to identify a critical molecule that potentially participates in endometriosis pathogenesis and characterize its correlation with dysmenorrhea and recurrence.Study designWe utilized a bioinformatics-based strategy to screen for candidate genes and fibroblast growth factor receptor 1(FGFR1) was chosen for further validation. FGFR1 expression was examined in specimens of ectopic and eutopic endometrium obtained from 48 patients with endometriosis and specimens of eutopic endometrium from 26 healthy control subjects using immunohistochemistry and Western blotting. In addition, FGFR shRNA treatment was applied in a nude mice endometriosis model to examine the functional role of FGFR1 in endometriosis formation in vivo.ResultsFGFR1 was found commonly overexpressed in ectopic endometrium of endometriosis compared with either its eutopic counterpart or endometrium from normal patients (P < 0.05). FGFR shRNA treatment impaired endometriosis formation and alleviated endometriosis-related symptoms in vivo. FGFR1 expression in ectopic endometrium was correlated with dysmenorrhea severity (P < 0.05) and recurrence in endometriosis patients (P < 0.05).Conclusion(s)FGFR1 might be involved in endometriosis development, which could possibly serve as a novel therapeutic target and prognostic marker for this disease.

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Condition tags

dysmenorrheaendometriosis

MeSH descriptors

Dysmenorrhea Endometriosis Endometrium Receptor, Fibroblast Growth Factor, Type 1 Animals Computational Biology Disease Models, Animal Dysmenorrhea Dysmenorrhea Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Endometriosis Endometriosis Endometrium Endometrium Female Gene Expression Profiling Humans

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References (21)

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