Circular Rna As A Potential Diagnostic And/Or Therapeutic Target for Endometriosis

Dana PM, Parisa Maleki Dana, Parisa M Dana, Mona Taghavipour, Taghavipour M, Hamed Mirzaei, Mirzaei H, Yousefi B, Bahman Yousefi, Moazzami B, Bahram Moazzami, Shahla Chaichian, Zatollah Asemi, Asemi Z
Biomarkers in medicine · 2020 · vol. 14(13) , pp. 1277–1287 · doi:10.2217/bmm-2020-0167 · PMID:33021386 · W3090320879
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This review summarizes the roles of circRNAs in endometriosis pathogenesis, particularly through miRNA networks and apoptosis, and highlights their potential as diagnostic and therapeutic targets.

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Abstract

Endometriosis is a pathology form of endometrium that behaves in a similar way to malignancies, such as invasion and resistance to apoptosis. Circular RNAs (CircRNAs) are a class of noncoding RNAs that have several biological functions including, miRNA sponging, sequestering of proteins, enhancing parental gene expression and translation resulting in polypeptides. In this review, we highlighted the roles of circRNAs as potential diagnostic and therapeutic biomarkers in endometriosis. Moreover, we summarized the roles of circRNAs in the pathogenesis of endometriosis via different signaling pathways, such as the miRNA network and apoptosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis RNA, Circular Animals Apoptosis Endometriosis Endometriosis Endometriosis Endometriosis Female Humans RNA, Circular Signal Transduction

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (90)

Cited by (9)

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License: CC0 · commercial use OK