Circular RNA as a potential diagnostic and/or therapeutic target for endometriosis

Dana PM, Parisa Maleki Dana, Parisa M Dana, Mona Taghavipour, Taghavipour M, Hamed Mirzaei, Mirzaei H, Yousefi B, Bahman Yousefi, Moazzami B, Bahram Moazzami, Shahla Chaichian, Zatollah Asemi, Asemi Z
Biomarkers in medicine · 2020 · vol. 14(13) , pp. 1277–1287 · doi:10.2217/bmm-2020-0167 · PMID:33021386 · W3090320879
Review OA: closed CC0 ⤵ 9 in-corpus citations
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This review summarizes the roles of circRNAs in endometriosis pathogenesis, particularly through miRNA networks and apoptosis, and highlights their potential as diagnostic and therapeutic targets.

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Abstract

Endometriosis is a pathology form of endometrium that behaves in a similar way to malignancies, such as invasion and resistance to apoptosis. Circular RNAs (CircRNAs) are a class of noncoding RNAs that have several biological functions including, miRNA sponging, sequestering of proteins, enhancing parental gene expression and translation resulting in polypeptides. In this review, we highlighted the roles of circRNAs as potential diagnostic and therapeutic biomarkers in endometriosis. Moreover, we summarized the roles of circRNAs in the pathogenesis of endometriosis via different signaling pathways, such as the miRNA network and apoptosis.

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Condition tags

endometriosis

MeSH descriptors

Endometriosis RNA, Circular Animals Animals Apoptosis Apoptosis Endometriosis Endometriosis Endometriosis Endometriosis Endometriosis Female Female Humans Humans RNA, Circular RNA, Circular Signal Transduction Signal Transduction

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

References (90)

Cited by (9)

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License: CC0 · commercial use OK