Association between genetic polymorphisms in fibroblast growth factor (FGF)1 and FGF2 and risk of endometriosis and adenomyosis in Chinese women

Shan Kang, Shi-Zhen Li, Li Shizhen, Na Wang, N. Wang, Rongmei Zhou, Rong-Miao Zhou, Tao Wang, Tiange Wang, D.-J. Wang, Dong-Jie Wang, Xiao-Fei Li, Xiaofeng Li, J. Bui, Jack Bui, Yan Li
Human Reproduction · 2010 · vol. 25(7) , pp. 1806–1811 · doi:10.1093/humrep/deq128 · PMID:20504870 · W2106008850
article OA: bronze CC0 ⤵ 34 in-corpus citations
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The FGF1 -1385A/G polymorphism showed a lower A allele frequency in endometriosis patients, while the FGF2 754C/G polymorphism's G allele was associated with decreased risk for both endometriosis and adenomyosis in Chinese women.

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Abstract

BACKGROUND: Angiogenesis appears to be an important event in the pathophysiology of endometriosis (EM) and adenomyosis. Two angiogenic factors, fibroblast growth factor (FGF) 1 and 2, play a central role in the initiation of angiogenesis. We investigated whether FGF1 -1385A/G and FGF2 754C/G polymorphisms are associated with a risk of developing EM and adenomyosis. METHODS: Genotypes were analyzed by the PCR-restriction fragment length polymorphism method in two groups of women, of Han ethnicity in north China, aged 16-55 years: (1) 421 EM patients and 421 controls; (2) 269 adenomyosis patients and 269 controls. RESULTS: There was no difference in genotype distribution of the FGF1 -1385A/G polymorphism between adenomyosis cases and controls (P > 0.05), but the frequency of the A allele in EM patients was lower than that in controls (P = 0.013). Genotype and allele frequencies of the FGF2 754C/C polymorphism were significantly different in both EM and adenomyosis cases versus control groups. Compared with C/C homozygotes, the G allele (C/G + G/G) was associated with a decreased susceptibility to developing EM [odds ratio (OR) = 0.575, 95% confidence interval (CI) = 0.387-0.854] and adenomyosis (OR = 0.577, 95% CI = 0.367-0.906). Combined genotype analysis of both polymorphisms also showed differences between cases versus controls (all P < 0.001). CONCLUSIONS: Our study shows for the first time that the FGF2 754C/G polymorphism may be associated with a risk of developing EM and adenomyosis in north Chinese women. Carriers of the G allele in the FGF2 gene appear to be protected from these gynecological diseases. Further studies in other populations, and of other candidate genes, are now warranted.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Fibroblast Growth Factor 1 Fibroblast Growth Factor 2 Polymorphism, Single Nucleotide Adolescent Adult Case-Control Studies China China Endometriosis Endometriosis Female Fibroblast Growth Factor 1 Fibroblast Growth Factor 2 Gene Frequency Genetic Predisposition to Disease Genotype Humans Middle Aged Promoter Regions, Genetic

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