Retrospective Study on the Incidence of Benign, Premalignant, and Malignant Gynecologic Disorders in Patients with Adenomyosis: Analysis of 5648 Specimens

Yunlei Cao, Cenyu Li, Ding Ding
In: Research Square · 2024 · doi:10.21203/rs.3.rs-4448561/v1 · W4399498024
preprint OA: green CC0
📄 Open PDF View on OpenAlex View at publisher
⚙ AI-generated summary by claude@2026-06, 2026-06-09 ⓘ

This retrospective study analyzed 5648 specimens and found that 82.3% of women with adenomyosis also had other gynecological pathologies, with uterine leiomyoma, endometrial cancer, and endometriosis being the most common.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

Abstract

Abstract Adenomyosis is an estrogen-dependent disease and ranks among the most common gynecological benign conditions in women of childbearing age. Adenomyosis has been reported to coincide with endometrial hyperplasia, polyps, and even endometrial cancer. This study aims to investigate the incidence of benign, premalignant, and malignant gynecological diseases in women undergoing gynecological surgery for adenomyosis. A retrospective review of medical records collected from January 2021 to May 2023 for surgeries performed at the Obstetrics and Gynecology Hospital affiliated with Fudan University was conducted. Pathology reports of 5648 cases of adenomyosis were studied. The incidence of benign, premalignant, and malignant gynecological pathologies in women with adenomyosis who underwent gynecological surgery were analyzed. The mean age of women with adenomyosis was 49.0 ± 9.0 years. Adenomyosis without other gynecological pathologies was detected in 16.7% of specimens of 5648 patients, while coexistence with one or more gynecological pathologies was present in 82.3% of cases. Additionally, coexistence with two or more gynecological diseases (benign or malignant) was present in 1806 of 5648 patients (31.9%). The most common comorbidities were uterine leiomyoma (57.1%), followed by endometrial cancer (11.8%) and endometriosis (10.7%). Furthermore, we found that women with adenomyosis, leiomyoma, endometriosis, endometrial polyps, or atypical hyperplasia were younger (p < 0.05) compared with adenomyotic patients with malignant tumors. Adenomyosis is a common benign, progressive disease that has garnered increasing attention in recent years. Some studies have suggested a potential association of adenomyosis with several gynecological diseases. Our study shows a high prevalence of endometrial cancer in patients with adenomyosis compared to the general population.

My notes (saved in your browser only)

Condition tags

endometriosisadenomyosis

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

Source provenance

europepmc
last seen: 2026-06-04T01:45:00.660873+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
License: CC0 · commercial use OK