Li C

This study aimed to investigate the impacts of granulocyte colony-stimulating factor (G-CSF) and platelet-rich plasma (PRP) on the pregnancy outcomes of infertile individuals with endometriosis after in vitro fertilization and embryo transf…

BACKGROUND: Smoking and alcohol consumption have been consistently associated with adverse female reproductive outcomes; however, whether these associations reflect causal effects or are mediated by specific circulating metabolites remains …

BackgroundPredicting clinical pregnancy following intrauterine insemination (IUI) remains challenging because of the complex interplay of multiple biological and treatment-related factors. Machine learning approaches may improve predictive …

BACKGROUND: Adenomyosis frequently coexists with other gynecological diseases, but the full spectrum of comorbidities and malignant conditions in surgically treated patients remain uncharacterized. This study sought to delineate concurrent …

Epithelial-mesenchymal transition (EMT) is a flexible cell-state program that supports tumor invasion, metastasis, immune escape, and therapy resistance. It is not a simple switch from an epithelial to a mesenchymal phenotype. Instead, canc…

OBJECTIVE: Approximately 20% of adenomyosis cases occur in women under 40 years of age [1]. Although LNG-IUD is the first-line medical therapy, its treatment failure is closely associated with uterine volume [2] with expulsion rates reporte…

Oocyte/embryo defects can result in oocyte maturation arrest, fertilization failure, embryonic arrest, and infertility as well as recurrent in vitro fertilization (IVF) or intracytoplasmic sperm injection (ICSI) failures. However, the genet…

BACKGROUND: Expulsion of the levonorgestrel-releasing intrauterine system (LNG-IUS) limits its effectiveness in adenomyosis management, particularly in patients with anatomical risk factors. This study aimed to assess the feasibility and sh…

ObjectiveTo identify independent risk factors for fertilization failure (FF) during conventional in vitro fertilization (IVF) and to develop a predictive model for clinical risk stratification.MethodsThis retrospective study included 2,474 …

ObjectiveObesity impairs endometrial receptivity; however, the mechanism remains unclear. Obesity is associated with elevated leptin levels, and leptin receptor (Ob-Rb) has been demonstrated to be expressed in the human endometrium, but the…

Endometriosis is a prevalent gynecological disorder characterized by ectopic growth of endometrial-like tissue, often causing chronic pain, infertility, and systemic inflammation. Accurate detection and complete surgical resection remain ch…

LPM7100328 is a novel oral GnRH antagonist being developed for the prevention of premature luteinizing hormone (LH) surges in women undergoing controlled ovarian stimulation. The studies presented herein reported assessment of safety in fav…

Perfluorooctanoic acid (PFOA) has been implicated in female reproductive toxicity, while its long-term effects of prenatal exposure remain unclear. Herein, we conducted a comprehensive NHANES analysis to estimate the Hazard Ratio (HR) of ea…

BackgroundAbdominal pregnancy refers to the implantation of a fertilized egg in the abdominal cavity outside of the uterus, fallopian tubes, and ovaries; splenic pregnancy is a rare type of abdominal pregnancy.Case presentationOur patient w…

N 6-methyladenosine (m6A) and N6, 2'-O-dimethyladenosine (m6Am) are two RNA modifications that play essential roles in diverse RNA metabolic processes and functions. Despite their importance, the dynamic landscapes and regulatory patterns o…

Endometriosis is a chronic, estrogen-dependent gynecologic disorder characterized by the ectopic growth of endometrial tissue outside the uterus. Zinc finger protein 143 (ZNF143) is a DNA-binding transcription factor, yet its role in endome…

OBJECTIVE: This study aimed to assess the efficacy of acupuncture combined with Chinese herbal medicine (CHM) on endometriosis-associated pain. METHODS: We searched eight electronic databases (PubMed, Web of Science, EMBASE, the Cochrane L…

BackgroundTo a large extent, the ovarian reserve determines a woman's reproductive potential. The etiological and pathological mechanisms of diminished ovarian reserve (DOR) remain unclear, and no reliable treatment is currently available f…

Deep infiltrating endometriosis (DIE) is a severe condition frequently linked to infertility, yet the optimal integration of surgery and assisted reproductive technology (ART) remains controversial. This study reports two cases of infertili…

There is a critical need to generate age- and sex-specific survival curves to characterize chronological aging consistently across nonhuman primates (NHP) used in biomedical research. Sex-specific Kaplan-Meier survival curves were computed …

PURPOSE: Endometriosis (EMS) is a chronic gynecological disorder with unclear pathogenesis. While the vaginal and gut microbiomes are known to influence EMS, few studies have analyzed both microbiomes integrally. This study aims to characte…

Yiming Zhao,1,2,* Xinyu Hu,1,* Chunyan Li,2 Jing Huang,3 Ke Guo,4 Qiong Pan,1 Zheng Yu2 1Department of Obstetrics and Gynecology, the Third Xiangya Hospital of Central South University, Changsha, People’s Republic of China; 2Human M…

We aimed to examine abnormal oxidative lipid levels and their related mechanisms in EM-associated infertility. Through liquid chromatography tandem mass spectrometry analysis, decreased levels of epoxyeicosatrienoic acids (EETs), which have…