Serum differential proteomic analysis of endometriosis and adenomyosis by iTRAQ technique

Xiaoyu L, Xiaoyu Long, Long Xiaoyu, Weiyuan Z, Weiyuan Zhang, Zhang Weiyuan, Ping J, Ping Jiang, Jiang Ping, Anxia W, Anxia Wan, Wan Anxia, Liane Zhou, Liane Z, Zhou Liane
European journal of obstetrics, gynecology, and reproductive biology · 2014 · vol. 182 , pp. 62–65 · doi:10.1016/j.ejogrb.2014.08.034 · PMID:25233445 · W2153432308
article OA: closed CC0 ⤵ 9 in-corpus citations
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This study used iTRAQ-based proteomic analysis to identify differentially expressed proteins in the serum of patients with endometriosis and adenomyosis.

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Abstract

Objective(s)Adenomyosis and endometriosis are two different diseases, although they have similar pathogenesis and characteristic. The serum differential expressed proteins in adenomyosis and endometriosis may result from the different pathogenesis of two diseases. Proteomic technology is a useful method for detecting all the proteins in samples. We try to use isobaric tags for relative and absolute quantitation (iTRAQ) technology to explore the association between the potential pathogenesis of these two diseases and these identified proteins.Study designThe serum samples from 20 patients with adenomyosis and from 20 patients with endometriosis were analyzed using iTRAQ technology to detect the differential expression of proteins. The validation of the proteins was performed using Western blot.ResultsIn the serum of women with adenomyosis and with endometriosis, 14 proteins were found differentially expressed using iTRAQ technology. Nine proteins were high-expression in adenomyosis group and four proteins increased in endometriosis group. And the differential expression proteins were validated by Western blot.Conclusion(s)The proteins increased in adenomyosis group are related to blood coagulation and complement activation effects, and the proteins high-expression in endometriosis mainly take part in the process of inflammatory response and regulation of apoptosis. The differentially expressed proteins in two groups may due to the different pathogenesis of two diseases.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Ovarian Diseases Proteome Proteomics Adenomyosis Biomarkers Biomarkers Blotting, Western Endometriosis Female Humans Ovarian Diseases Proteome Proteomics

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (15)

Cited by (9)

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License: CC0 · commercial use OK