Transmembrane G protein-coupled receptor 30 gene polymorphisms and uterine adenomyosis in Korean women

Dae Gy Hong, Ji Young Park, Gun Oh Chong, Yoon Hee Lee, Hyun Jung Lee, Jung Un Shinn, Yoon Soon Lee, Won Joon Seong
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology · 2019 · vol. 35(6) , pp. 498–501 · doi:10.1080/09513590.2018.1540572 · PMID:30626229 · W2910771312
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⚙ AI-generated summary by claude@2026-06, 2026-06-12 ⓘ

This study investigated GPR30 gene polymorphisms in Korean women and found that the rs3802141 CT genotype was more frequent in controls, while the rs4266553 CC genotype and C allele were more common in adenomyosis patients.

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Abstract

To compare the genetic distributions of 14G protein-coupled receptor 30 (GPR30) single-nucleotide polymorphisms (SNPs) between women with and without uterine adenomyosis. The study population comprised 69 Korean women. Uterine tissues from the adenomyosis and non-adenomyosis groups were used for DNA extraction. Pre-designed PCR/Sanger or Sequencing Primer and TaqMan® SNP Genotyping Assays were used for the SNP genotyping of the GPR30 gene. Immunohistochemical staining was performed to confirm the GPR30 expression. Differences in genotype and allele frequencies between the two groups were calculated using Fisher’s exact test. The rs3802141 CT genotype was more common in the control group (p = .02), and the rs4266553 CC genotype was more common in the adenomyosis group (p = .02). The C allele of the SNP rs4266553 was more common in the adenomyosis group (p = .02). GPR30 expression was confirmed in 69 individuals in both groups. GPR30 gene polymorphism is presumed to affect the risk of adenomyosis with limited sample size. Further large-scale study is needed to explain the genetic influence of GPR30 gene polymorphism.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Polymorphism, Single Nucleotide Receptors, Estrogen Receptors, G-Protein-Coupled Adenomyosis Adult Aged Alleles Female Gene Frequency Genetic Predisposition to Disease Genotype Humans Middle Aged Receptors, Estrogen Receptors, G-Protein-Coupled Republic of Korea

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