Effect of matrix metalloproteinase promoter polymorphisms on endometriosis and adenomyosis risk: evidence from a meta-analysis

Hui Ye, Yazhou He, Jiarong Wang, Tiange Song, Lan Zhu, Zhu Lan, Yiqi Zhao, Mingrong Xi
Journal of genetics · 2016 · vol. 95(3) , pp. 611–619 · doi:10.1007/s12041-016-0675-5 · PMID:27659332 · W2477101755
review OA: closed CC0 ⤵ 19 in-corpus citations
Limited metadata. Only one source feed has indexed this record so far — no abstract, full text, or open-access copy is available through Endo Lab. The publisher's page (linked below) is the canonical location for the actual content. If you have institutional access, use "Find at my library".
View at publisher → View on OpenAlex View on PubMed
⚙ AI-generated summary by claude@2026-06+body, 2026-06-06 ⓘ

This meta-analysis found an association between the MMP-1 -1607 1G/2G polymorphism and increased endometriosis and adenomyosis risk, but not for MMP-2, MMP-3, or MMP-9 polymorphisms.

One-sentence paraphrase of the abstract; not a substitute for reading it. No clinical advice. How this works

⚙ AI-generated deep summary by claude@2026-06, 2026-06-06 ⓘ

This meta-analysis systematically reviewed studies examining associations between matrix metalloproteinase (MMP) promoter polymorphisms (MMP-1 -1607 1G/2G, MMP-2 -735 C/T, MMP-3 -1171 5A/6A, and MMP-9 -1562 C/T) and the risk of endometriosis and adenomyosis, using pooled odds ratios and study quality assessment via the Newcastle–Ottawa scale. Across 13 papers (18 studies), the MMP-1 -1607 1G/2G polymorphism showed a significant association with endometriosis and adenomyosis susceptibility under a recessive model (OR=1.25, 95% CI 1.03–1.53, P=0.03), while no significant associations were observed for the MMP-2, MMP-3, or MMP-9 polymorphisms. The authors explicitly note the need for more well-designed, large-scale studies, including gene–gene and gene–environment interaction analyses. This paper is centrally about endometriosis and adenomyosis — it evaluates how MMP promoter polymorphisms influence risk through a pooled meta-analytic approach.

Read from the paper's body, not the abstract. Not a substitute for reading the paper. No clinical advice. How this works

My notes (saved in your browser only)

Condition tags

mesh:D004715endometriosisadenomyosis

MeSH descriptors

Adenomyosis Endometriosis Matrix Metalloproteinase 1 Matrix Metalloproteinase 2 Matrix Metalloproteinase 3 Matrix Metalloproteinase 9 Polymorphism, Single Nucleotide Adenomyosis Adenomyosis Adenomyosis Endometriosis Endometriosis Endometriosis Female Gene-Environment Interaction Gene Expression Genetic Predisposition to Disease Humans Matrix Metalloproteinase 1 Matrix Metalloproteinase 2

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (44)

Cited by (19)

Source provenance

europepmc
last seen: 2026-06-04T01:30:01.192114+00:00
openalex
last seen: 2026-06-10T17:14:06.276822+00:00
pubmed
last seen: 2026-05-13T22:20:54.390225+00:00
License: CC0 · commercial use OK