Adenomyosis demonstrates increased expression of the basic fibroblast growth factor receptor/ligand system compared with autologous endometrium

Anthony M. Propst, Propst AM, A M Propst, Quade BJ, B J Quade, Bradley J. Quade, A R Gargiulo, Antonio Gargiulo, Gargiulo AR, Nowak RA, Romana A. Nowak, R A Nowak, Stewart EA, E A Stewart, Elizabeth A. Stewart
Menopause (New York, N.Y.) · 2001 · vol. 8(5) , pp. 368–371 · doi:10.1097/00042192-200109000-00012 · PMID:11528364 · W2020370899
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Adenomyosis tissues exhibited significantly higher expression of bFGF, FGF-R, and PCNA compared to autologous endometrium.

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This study utilized immunohistochemistry to compare the expression of basic fibroblast growth factor (bFGF), its type 1 receptor, and the proliferation marker PCNA in adenomyotic tissue versus autologous endometrium from menopausal women. The researchers found significantly greater staining intensity for bFGF and FGF-R in the glandular epithelium of adenomyosis, alongside increased stromal staining for bFGF and PCNA relative to the endometrial controls. These results indicate that the upregulation of the bFGF receptor/ligand system and heightened cellular proliferation are distinct features of adenomyotic lesions compared to normal endometrium. This paper is centrally about adenomyosis — specifically investigating the molecular mechanisms involving growth factors that may contribute to abnormal uterine bleeding associated with the condition.

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Abstract

OBJECTIVES: Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium. Women with leiomyoma-related abnormal uterine bleeding have local dysregulation of bFGF and its type 1 receptor (FGF-R). This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium. DESIGN: Menopausal uteri containing endometrium and adenomyosis were analyzed using immunohistochemistry with monoclonal antibodies specific for bFGF, FGF-R, and proliferating cell nuclear antigen (PCNA), a marker of cellular proliferation. The expression and intensity of staining for bFGF, FGF-R, and PCNA were evaluated in the glandular epithelium and stroma of adenomyosis and endometrium. RESULTS: Glandular epithelial staining was significantly greater in adenomyosis compared with autologous endometrium for bFGF and FGF-R. Stromal staining for bFGF and PCNA was significantly increased in adenomyosis compared with autologous endometrium. CONCLUSIONS: Upregulation of the bFGF receptor/ligand system and increased cellular proliferation in adenomyosis may contribute to the pathogenesis of abnormal uterine bleeding associated with adenomyosis.
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Objectives

Basic fibroblast growth factor (bFGF) is an angiogenic growth factor present in human endometrium and myometrium. Women with leiomyoma-related abnormal uterine bleeding have local dysregulation of bFGF and its type 1 receptor (FGF-R). This study was designed to evaluate if adenomyosis expresses bFGF and FGF-R, and if present, to compare bFGF and FGF-R expression in adenomyosis and autologous endometrium. Design Menopausal uteri containing endometrium and adenomyosis were analyzed using immunohistochemistry with monoclonal antibodies specific for bFGF, FGF-R, and proliferating cell nuclear antigen (PCNA), a marker of cellular proliferation. The expression and intensity of staining for bFGF, FGF-R, and PCNA were evaluated in the glandular epithelium and stroma of adenomyosis and endometrium.

Results

Glandular epithelial staining was significantly greater in adenomyosis compared with autologous endometrium for bFGF and FGF-R. Stromal staining for bFGF and PCNA was significantly increased in adenomyosis compared with autologous endometrium.

Conclusions

Upregulation of the bFGF receptor/ligand system and increased cellular proliferation in adenomyosis may contribute to the pathogenesis of abnormal uterine bleeding associated with adenomyosis.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Endometriosis Endometrium Fibroblast Growth Factor 2 Receptors, Fibroblast Growth Factor Aged Aged, 80 and over Endometriosis Endometrium Female Fibroblast Growth Factor 2 Humans Immunohistochemistry Middle Aged Receptors, Fibroblast Growth Factor Up-Regulation Up-Regulation

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