Ulipristal Acetate Improves Clinical Symptoms in Women with Adenomyosis and Uterine Myomas

Meritxell Gràcia, Meritxell Gracia, Alcalà M, Marta Alcalà, Janisse Ferreri, Ferreri J, Rius M, Mariona Rius, Ros C, Cristina Ros, Adela Saco, María Adela Saco, Martínez-Zamora MÁ, María Ángeles Martínez-Zamora, Maria Ángeles Martínez‐Zamora, Francisco Carmona
Journal of minimally invasive gynecology · 2018 · vol. 25(7) , pp. 1274–1280 · doi:10.1016/j.jmig.2018.04.002 · PMID:29626678 · W2795713144
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Ulipristal acetate was investigated and found to improve clinical symptoms in women diagnosed with adenomyosis and uterine myomas.

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Abstract

Study objectiveTo study the effects of ulipristal acetate (UPA) on adenomyosis-associated clinical symptoms.DesignA retrospective, single-center observational study (Canadian Task Force classification II-2).SettingA university tertiary referral center.PatientsPremenopausal women (163) with adenomyosis and symptomatic uterine myomas (41 patients, A + F group) versus a control group with only myomas (122 patients, F group) treated with the first course of UPA.InterventionsThis was a retrospective study to assess the effects of a 12-week course of UPA (5 mg/d).Measurements and main resultsClinical symptoms including bleeding control, amenorrhea, pain outcomes, and self-perceived severity of the disease and quality of life. Amenorrhea was present in 90.4% of the A + F group compared with 77.6% in the F group (p = .0017). Optimal bleeding control was significantly higher in the adenomyosis group (pictorial blood loss assessment chart < 75) than in the F group (90.2% vs 73.8%, p = .028). At the end of the first UPA course, the self-reported visual analog scale scores in the A + F group were significantly higher than in the F group (p = .017), reflecting greater improvement in pain outcomes for women with adenomyosis. UPA treatment improved the quality of life in both study groups. Most of the women rated their global health status as "better" after the first UPA course than before the treatment (A + F group: 67.00% and F group: 80.50%, p = .223).ConclusionTreatment with UPA led to a significant reduction in the clinical symptoms of adenomyosis (bleeding and pain) and achieved a high rate of amenorrhea in a cohort of women with concomitant uterine myomas. Despite the limitations of the study, our results showed that UPA might be a good alternative treatment for adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Contraceptive Agents, Female Leiomyoma Norpregnadienes Uterine Neoplasms Adenomyosis Adenomyosis Adult Contraceptive Agents, Female Female Humans Leiomyoma Leiomyoma Middle Aged Norpregnadienes Retrospective Studies Treatment Outcome Uterine Neoplasms Uterine Neoplasms

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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