Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis

Nie J, Jichan Nie, Liu X, Xishi Liu, Guo SW, Sun-Wei Guo, Sun‐Wei Guo
American journal of obstetrics and gynecology · 2010 · vol. 202(4) , pp. 346.e1–346.e8 · doi:10.1016/j.ajog.2009.11.035 · PMID:20096818 · W2043641311
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This study investigated the immunoreactivity of the oxytocin receptor and TRPV1 and their correlation with dysmenorrhea in patients with adenomyosis.

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Abstract

ObjectiveWe sought to investigate the expression and localization of oxytocin receptor (OTR) and transient receptor potential vanilloid type 1 (TRPV1) in women with and without adenomyosis.Study designEctopic and homologous eutopic endometrium from 50 women with adenomyosis and endometrium from 18 women without adenomyosis were used for immunohistochemical analysis of OTR and TRPV1. Microscopic evaluation assessed the presence and localization of OTR and TRPV1 throughout the menstrual cycle in both eutopic endometrial and endometriotic tissues of women with adenomyosis and compared them with normal endometrium.ResultsCompared with normal endometrium, immunoreactivity of OTR and TRPV1 were significantly increased in ectopic endometrium. Both OTR and TRPV1 immunoreactivity were positively correlated with the severity of dysmenorrhea and found to be significant predicators for dysmenorrhea severity.ConclusionThese findings suggest that OTR and TRPV1 may be involved in dysmenorrhea and its severity in adenomyosis and may be potential therapeutic targets.

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Condition tags

dysmenorrheaendometriosisadenomyosis

MeSH descriptors

Dysmenorrhea Endometriosis Receptors, Oxytocin TRPV Cation Channels Uterus Adult Antibodies Cytoplasm Cytoplasm Cytoplasm Dysmenorrhea Dysmenorrhea Endometriosis Endometriosis Female Humans Immunohistochemistry Menstruation Middle Aged Predictive Value of Tests

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Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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