Update of recent studies of adenomyosis-associated dysmenorrhea
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This review examines the pathophysiology of adenomyosis-associated dysmenorrhea, highlighting the roles of oxytocin, inflammatory factors, prostaglandin F2α, and pelvic splanchnic nerve pathways.
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Abstract
Adenomyosis is characterized by invasion of endometrial glands and stromal cells into the myometrium. It is a common gynecological disorder that usually occurs in women during their reproductive years. The primary clinical manifestations of adenomyosis are menorrhagia and progressive dysmenorrhea. The pathogenesis of adenomyosis-associated dysmenorrhea is complicated. However, it is predicted that oxytocin, inflammatory factors, and prostaglandin F2α are responsible for adenomyosis-associated dysmenorrhea via the induction of uterine smooth muscle contractions. Additionally, the pain conductivity of the pelvic viscera (internal organs) involves both the sympathetic (T10–L1) and parasympathetic (S2–4) nervous systems located in the abdominal region. This article provides a review of the pathophysiology of dysmenorrhea in adenomyosis and the nociceptive afferent pathway of the pelvic splanchnic nerves.
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Cited by (11)
- Ruptured Pedunculated Adnomyoma with Cystic Degeneration in a Postmenopausal Woman: A Case Report and Literature Review 2025
- Vaginal microbiome of women with adenomyosis: A case-control study 2022
- Insights on Adenomyosis Development 2022
- Diagnosis of endometriosis by detection of nerve fibers using protein gene product 9.5 immunohistochemistry 2021
- Comparison of dienogest versus combined oral contraceptive pills in the treatment of women with adenomyosis: A randomized clinical trial 2021
- Treating Deep Endometriosis in Infertile Patients before Assisted Reproductive Technology 2021
- Laparoscopic “Shaving” for Infiltrative External Adenomyosis of Bowel Muscularis and Concomitant Deep Infiltrating Endometriosis 2021
- Laparoscopic Uterine Artery Occlusion Combined with Uterine-sparing Pelvic Plexus Block and Partial Adenomyomectomy for Adenomyosis: A Video Case Report 2021
- The new application of mifepristone in the relief of adenomyosis-caused dysmenorrhea 2020
- Oxytocinergic regulation in pathogenesis of pelvic pain caused by adenomyosis 2020
- Computed Tomography-Guided Superior Hypogastric Plexus Block for Secondary Dysmenorrhea in Perimenopausal Women 2018
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