Treatment of adenomyosis with long-term GnRH analogues: a case report.
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Long-term GnRH analogue treatment of biopsy-proven adenomyosis reduced uterine volume by 65% and relieved dysmenorrhea with amenorrhea.
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Abstract
Presented here is the first reported case of biopsy-proved adenomyosis treated medically with long-term GnRH analogue. Uterine volume, as calculated by serial ultrasound measurements, was reduced by 65% after 4 months and remained small several months after discontinuation of therapy. Size reduction was accompanied by amenorrhea and relief of severe dysmenorrhea. Though not proposed as a substitute for surgery, GnRH analogue may be useful as a surgical adjuvant or for temporary reduction of symptoms.
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