Treatment of adenomyosis with long-term GnRH analogues: a case report
Case report
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Long-term GnRH analogue treatment of biopsy-proven adenomyosis reduced uterine volume by 65% and relieved dysmenorrhea with amenorrhea.
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Abstract
Presented here is the first reported case of biopsy-proved adenomyosis treated medically with long-term GnRH analogue. Uterine volume, as calculated by serial ultrasound measurements, was reduced by 65% after 4 months and remained small several months after discontinuation of therapy. Size reduction was accompanied by amenorrhea and relief of severe dysmenorrhea. Though not proposed as a substitute for surgery, GnRH analogue may be useful as a surgical adjuvant or for temporary reduction of symptoms.
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Cited by (50)
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- Progesterone Actions and Resistance in Gynecological Disorders 2022
- Efficacy of High-Intensity Focused Ultrasound Combined With GnRH-a for Adenomyosis: A Systematic Review and Meta-Analysis 2021
- Uterine Adenomyosis: From Disease Pathogenesis to a New Medical Approach Using GnRH Antagonists 2021
- Shi Xiao San ameliorates the development of adenomyosis in an ICR mouse model 2020
- High-intensity focused ultrasound (HIFU) combined with gonadotropin-releasing hormone analogs (GnRHa) and levonorgestrel-releasing intrauterine system (LNG-IUS) for adenomyosis: a case series with long-term follow up 2019
- Recurrence of uterine adenomyosis after administration of gonadotropin-releasing hormone agonist and the efficacy of dienogest 2019
- A critical review of recent advances in the diagnosis, classification, and management of uterine adenomyosis 2019
- Benign Uterine Diseases 2019
- Efficacy of Hormonal Therapies for Decreasing Uterine Volume in Patients with Adenomyosis 2018
- The Possible Role of Eukaryotic Translation Initiation Factor 3 Subunit e (eIF3e) in the Epithelial-Mesenchymal Transition in Adenomyosis 2018
- A clinical audit on the efficacy and safety of uterine artery embolisation for symptomatic adenomyosis: Results in 117 women 2018
- THE CLINICAL EFFICACY OF SEQUENTIAL USE OF GONADOTROPIN-RELEASING HORMONE ANALOG - LEVONORGESTREL-RELEASING INTRAUTERINE SYSTEM IN MEDICALLY ILL WOMEN WITH SYMPTOMATIC AND RELATIVELY LARGE ADENOMYOSIS 2018
- Long-term dienogest administration in patients with symptomatic adenomyosis 2018
- Adenomyosis and Subfertility 2018
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- Treatment options and reproductive outcome for adenomyosis-associated infertility 2017
- Adenomyosis: a systematic review of medical treatment 2016
- Corroborating evidence for platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis 2016
- Clinical Predictors of Long-term Success in Ultrasound-guided High-intensity Focused Ultrasound Ablation Treatment for Adenomyosis: A Retrospective Study 2016
- A mass spectrometric insight into the origins of benign gynecological disorders 2015
- Current Treatment for Adenomyosis 2015
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- Methodological Issues in Preclinical Mouse Efficacy Studies of Adenomyosis 2012
- Adenomyosis: review of the literature 2011
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- Immunoreactivity of oxytocin receptor and transient receptor potential vanilloid type 1 and its correlation with dysmenorrhea in adenomyosis 2010
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- High-intensity focused ultrasound ablation of uterine localized adenomyosis 2010
- Promoter hypermethylation of progesterone receptor isoform B (PR-B) in adenomyosis and its rectification by a histone deacetylase inhibitor and a demethylation agent 2010
- Implantation failure: molecular mechanisms and clinical treatment 2010
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- Hormonal treatments for adenomyosis 2007
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- A pilot study on the off-label use of valproic acid to treat adenomyosis 2007
- Current diagnostic and treatment strategies for adenomyosis 2006
- Long-term results of uterine artery embolization for symptomatic adenomyosis 2006
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