The symptomatology of adenomyosis
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This paper describes the symptoms associated with adenomyosis.
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Abstract
Adenomyosis is a poorly understood condition which has been called 'elusive' or 'enigmatic' because of the difficulty in diagnosis, the lack of agreement on definition, and also because of the vague and ill-defined pattern of symptoms which may accompany it. There is little doubt that some women with adenomyosis may experience troublesome, heavy menstrual bleeding, troublesome dysmenorrhoea, and sometimes a tender uterus. However, the frequency and severity with which these symptoms occur, and the proportion of adenomyosis sufferers who are completely asymptomatic, are quite unclear. The common association of adenomyosis with other pelvic pathologies is an additional factor which confuses the understanding of related symptoms. It is clear that there is no specific combination of symptoms caused by adenomyosis, although many of these women will undoubtedly suffer from very heavy menstrual periods. Now that moderate to severe degrees of adenomyosis can be diagnosed preoperatively with a fair degree of reliability by good-quality ultrasound or magnetic resonance imaging (MRI), there is an urgent need for multicentre collaboration to prospectively define symptomatology in a uniform manner, and then correlate this with specific findings on imaging (and compare with later surgical and pathological findings).
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Cited by (50)
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- Spatial transcriptomics uncovers the hybrid molecular identity, ciliated phenotype, and immune signature of adenomyosis lesions 2026
- Evaluation of quality of life in women with severe diffuse adenomyosis before and after organ-preserving surgery 2026
- The Adenomyosis and infertility - underestimated challenge in reproductive medicine 2025
- Effectiveness and safety of adjuvant therapy of chinese herbal medicine for adenomyosis: A systematic review and meta-analysis of randomized controlled trials 2025
- The downregulation of FKBP5 contributes to the pathogenesis of adenomyosis and is associated with impaired endometrial receptivity† 2025
- Additional file 1 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Association of Uterine Tissue Innervation and Peripheral Nerve Density with Adenomyosis Related Pain. A Systematic Review 2024
- Adenomyosis: A Call for Awareness, Early Detection and Effective Treatment Strategies 2024
- Occult clear cell carcinoma arising from oxidative stress‑exposed cystic adenomyosis: A case report 2024
- Additional file 5 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Additional file 4 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Additional file 3 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Epidemiological characteristics of suspected adenomyosis in the Chinese physical examination population: a nested case-control study 2024
- Additional file 2 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Controversial Roles of Autophagy in Adenomyosis and Its Implications for Fertility Outcomes-A Systematic Review 2024
- Ultrasound Assisted Synthesis of Starch-green Tea Extract Composite and its Therapeutic Effects on Adenomyosis by Following the MAPK/ERK Signaling and Pro-inflammatory Pathways in Mice 2024
- Additional file 3 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Additional file 1 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Additional file 2 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Additional file 5 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Adenomyosis-A Call for Awareness, Early Detection, and Effective Treatment Strategies: A Narrative Review 2024
- Additional file 4 of Transcriptome analysis of adenomyosis eutopic endometrium reveals molecular mechanisms involved in adenomyosis-related implantation failure and pregnancy disorders 2024
- Activation of HAND2-FGFR signaling pathway by lncRNA HAND2-AS1 in adenomyosis† 2023
- Estradiol-Progesterone Balance Paradigm: Heavy Menstrual Flow 2023
- Histopathological characteristics of adenomyosis: structure and microstructure 2023
- Diagnosis and Treatment of Adenomyosis with Office Hysteroscopy-A Narrative Review of Literature 2023
- Evaluation of Levonorgestrel-Releasing Intrauterine System (LNG) in The Management of Uterine Adenomyosis: An Update Systematic Review and Meta- Analysis 2023
- Tumor rupture and partial gut obstruction: Atypical presentations in a patient with adenomyosis 2023
- 5-Hydroxymethylcytosine profiles in circulating cell-free DNA serve as potential biomarkers for diagnosis and classification of adenomyosis 2023
- Endometrial cancer arising from adenomyosis with unusual manifestation: A case report 2023
- The role of the junctional zone in the management of adenomyosis with infertility 2023
- Abnormal Uterine Bleeding in Reproductive Age Women: Role of Imaging in the Diagnosis and Management 2023
- Characterising the immune cell phenotype of ectopic adenomyosis lesions compared with eutopic endometrium: A systematic review 2023
- MIR503HG silencing promotes endometrial stromal cell progression and metastasis and suppresses apoptosis in adenomyosis by activating the Wnt/β‑catenin pathway via targeting miR‑191 2023
- Comparison of high-intensity focused ultrasound for the treatment of internal and external adenomyosis based on magnetic resonance imaging classification 2023
- The Asian Society of Endometriosis and Adenomyosis guidelines for managing adenomyosis 2023
- Measures of fetal growth and preterm birth and risk of endometriosis and adenomyosis in adult life: a systematic review and meta-analysis 2023
- Endometriosis Symptoms and Their Impacts on the Daily Lives of US Women: Results from an Interview Study 2023
- The Menstrual Endometrium: From Physiology to Future Treatments 2022
- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- Classification of Uterine Adenomyosis 2022
- The use of the myometrial‐cervical ratio in the ultrasound diagnosis of adenomyosis – A validation study 2022
- Uterine bleeding: how understanding endometrial physiology underpins menstrual health 2022
- RETROSPECTIVE ANALYSIS OF CHANGING TRENDS IN PRESENTATION AND MANAGEMENT OF ADENOMYOSIS 2022
- Acute recurrent cerebral infarction caused by moyamoya disease complicated with adenomyosis: A case report 2022
- Uterine Embolization as a New Treatment Option in Adenomyosis Uteri 2022
- In Search of an Imaging Classification of Adenomyosis: A Role for Elastography? 2022
- Adjustment of progesterone administration after endometrial transcriptomic analysis does not improve reproductive outcomes in women with adenomyosis 2022
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