Histopathological characteristics of adenomyosis: structure and microstructure

Liu Z, Ziyu Liu, Yanxian Guo, Guo Y, Xinyi Pan, Pan X, Guihua Liu, Liu G, Yang X, Xing Yang
Histology and histopathology · 2023 · vol. 38(10) , pp. 1099–1107 · doi:10.14670/hh-18-594 · PMID:36808615 · W4321478576
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This review describes the histopathological characteristics, classification, molecular markers, and treatment-related changes of adenomyosis, a benign uterine disease involving endometrial tissue within the myometrium.

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This article reviews the histopathological features of adenomyosis, a benign uterine disease defined by the presence of endometrial glands and stroma within the myometrium. It summarizes the current state of knowledge on the major pathological aspects, discusses points of disagreement regarding the histopathological “gold standard” definition and how adenomyosis can be categorized based on histology, and includes clinical findings for uncommon forms of adenomyosis. The paper also describes histological alterations reported in adenomyosis after medicinal therapy, while noting that diagnostic accuracy has improved through identification of unique molecular markers. This paper is centrally about adenomyosis—histopathological characteristics, structure/microstructure, and histology-based classification, including post-therapy histological changes.

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Abstract

Adenomyosis is a benign uterine disease that pathologically shows endometrial glands and stroma in the myometrium. There are multiple lines of evidence that adenomyosis is associated with abnormal bleeding, painful menstruation, chronic pelvic pain, infertility, and spontaneous pregnancy loss. Pathologists have researched adenomyosis by studying tissue specimens from its first report more than 150 years ago, and differing viewpoints on its pathological alterations have been advanced. However, the gold standard histopathological definition of adenomyosis remains controversial to date. The diagnostic accuracy of adenomyosis has steadily increased due to the continual identification of unique molecular markers. This article provides a brief description of the pathological aspects of adenomyosis and discusses adenomyosis categorization based on histology. The clinical findings of uncommon adenomyosis are also presented to offer a thorough and detailed pathological profile. Furthermore, we describe the histological alterations in adenomyosis after medicinal therapy.
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Histopathological characteristics of adenomyosis: structure and microstructure Ziyu Liu1,2, Yanxian Guo1,2, Xinyi Pan1,2, Guihua Liu1,2 and Xing Yang1,2 1Reproductive Medicine Research Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou and 2GuanDong Engineering Technology Research Center of Fertility Preservation, Guangdong, PR China Corresponding Author: Xing Yang, Reproductive Medicine Research Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, PR China. e-mail: [email protected] or Guihua Liu, Reproductive Medicine Research Center, The Sixth Affiliated Hospital, Sun Yat-Sen University, Guangzhou, Guangdong, PR China. e-mail: [email protected] Summary. Adenomyosis is a benign uterine disease that pathologically shows endometrial glands and stroma in the myometrium. There are multiple lines of evidence that adenomyosis is associated with abnormal bleeding, painful menstruation, chronic pelvic pain, infertility, and spontaneous pregnancy loss. Pathologists have researched adenomyosis by studying tissue specimens from its first report more than 150 years ago, and differing viewpoints on its pathological alterations have been advanced. However, the gold standard histopathological definition of adenomyosis remains controversial to date. The diagnostic accuracy of adenomyosis has steadily increased due to the continual identification of unique molecular markers. This article provides a brief description of the pathological aspects of adenomyosis and discusses adenomyosis categorization based on histology. The clinical findings of uncommon adenomyosis are also presented to offer a thorough and detailed pathological profile. Furthermore, we describe the histological alterations in adenomyosis after medicinal therapy. Histol Histopathol 38, 1099-1107 (2023) Key words: Adenomyosis, Histopathology, Structure, Microstructure, Classification DOI: 10.14670/HH-18-594 | �The Author(s) 2023. Open Access. This article is licensed under a Creative Commons CC-BY International License. |

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Condition tags

adenomyosischronic_pelvic_paininfertility

MeSH descriptors

Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous Abortion, Spontaneous

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

References (64)

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