The Role of CD10 Staining in Distinguishing Invasive Endometrial Adenocarcinoma from Adenocarcinoma Involving Adenomyosis

Alessandra F Nascimento, Michelle S Hirsch, Aida Cviko, Aida Čviko, Bradley J Quade, Marisa R Nucci
Modern pathology : an official journal of the United States and Canadian Academy of Pathology, Inc · 2003 · vol. 16(1) , pp. 22–27 · doi:10.1097/01.mp.0000043523.03519.fc · PMID:12527709 · W2060567822
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⚙ AI-generated summary by claude@2026-06+body, 2026-06-08 ⓘ

CD10 expression in stromal cells distinguishes endometrial adenocarcinoma involving adenomyosis from true myometrial invasion.

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⚙ AI-generated deep summary by claude@2026-06, 2026-06-10 ⓘ

This study evaluated whether CD10 immunohistochemistry could help distinguish invasive endometrial adenocarcinoma (i.e., true myometrial invasion) from endometrial adenocarcinoma involving adenomyosis without myometrial invasion, using 39 hysterectomy specimens categorized into three groups (invasive carcinoma, adenomyosis involved without myometrial invasion, and adenomyosis involved with concurrent myometrial invasion). The key finding was that adenomyotic foci involved by carcinoma showed CD10 expression in adenomyosis stromal cells in all cases, whereas CD10 was absent in cells adjacent to invasive glands in many invasive cases; the authors further noted that CD10 positivity around neoplastic glands did not equate with adenomyosis involvement, because some invasive carcinomas showed CD10 in a desmoplastic or direct-invasion context. A limitation is the small number of cases in the invasive-only subgroups and the reliance on pathological staging criteria that can be challenging in practice. This paper is centrally about endometriosis — it specifically addresses distinguishing endometrial adenocarcinoma invading adenomyosis versus true myometrial invasion using CD10 staining patterns.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Adenocarcinoma Endometrial Neoplasms Endometriosis Neprilysin Adenocarcinoma Adenocarcinoma Adenocarcinoma Aged Biomarkers, Tumor Biomarkers, Tumor Diagnosis, Differential Endometrial Neoplasms Endometrial Neoplasms Endometrial Neoplasms Endometriosis Endometriosis Endometriosis Endometrium Endometrium Endometrium

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

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