Adenomyosis in Postmenopausal Breast Cancer Patients Treated with Tamoxifen: A New Entity?
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This paper investigates the occurrence of adenomyosis in postmenopausal women with breast cancer who have received tamoxifen treatment.
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Abstract
Between September 1, 1989 and October 31, 1994, 173 postmenopausal breast cancer women on tamoxifen treatment were followed up in the authors' institutions. During this period, 14 (8.1%) underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for various indications. Eight (57.1%) were found to have adenomyosis, of whom one had a large fundal adenomyotic lump and the other seven patients had two to four small microscopic foci of adenomyosis. In this study, the rate of adenomyosis described among those postmenopausal breast cancer patients treated with tamoxifen is nearly three to four times higher than the rate reported in the literature for pre- and postmenopausal women. There is no previous reported increased incidence of adenomyosis in postmenopausal breast cancer patients treated with tamoxifen. Thus, it is suggested that the prolonged and unopposed estrogen-like stimulation by tamoxifen may play a causal role rather than be a casual factor in the development of this pathologic entity.
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Cited by (36)
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- Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes 2020
- Diagnosis of uterine adenomyosis in patients of reproductive age 2020
- Epidemiology of Adenomyosis 2020
- Role of angiogenesis in adenomyosis-associated abnormal uterine bleeding and subfertility: a systematic review 2019
- Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy 2019
- Adenomyosis: A Sonographic Diagnosis 2018
- Coexistence of adenomyosis, adenocarcinoma, endometrial and myometrial lesions in resected uterine specimens 2018
- Adenomyosis: a systematic review of medical treatment 2016
- The Incidence and Clinical Significance of Adenomyosis 2015
- The Pathophysiology of Adenomyosis 2015
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Estradiol and tamoxifen enhance invasion of endometrial stromal cells in a three-dimensional coculture model of adenomyosis 2013
- Obstructive uropathy associated with primary ureteral endometrioma: case report and review of the literature 2013
- Adenomyosis: Review of the Literature 2011
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- Primary ovarian adenomyoma in a woman with endometrial polyp: a case report and review of the literature 2009
- Mesenchymal uterine tumors, other than pure smooth muscle neoplasms, and adenomyosis 2009
- Radiological Reasoning: Algorithmic Workup of Abnormal Vaginal Bleeding with Endovaginal Sonography and Sonohysterography 2008
- Uterine adenomyosis: a need for uniform terminology and consensus classification 2008
- Adenomyosis and ‘endometrial– subendometrial myometrium unit disruption disease’ are two different entities 2008
- Ovarian adenomyoma following gonadotrophin treatment for infertility 2006
- Spectrum of MR features in adenomyosis 2006
- Current diagnostic and treatment strategies for adenomyosis 2006
- MR Imaging Findings of Adenomyosis: Correlation with Histopathologic Features and Diagnostic Pitfalls 2005
- Florid polypoid endometriosis exacerbated by tamoxifen therapy in breast cancer 2003
- Transvaginal US and Hysterosonography in Postmenopausal Women with Breast Cancer Receiving Tamoxifen: Correlation with Hysteroscopy and Pathologic Study 2003
- Florid Polypoid Endometriosis Exacerbated by Tamoxifen Therapy in Breast Cancer 2003
- The Role of CD10 Staining in Distinguishing Invasive Endometrial Adenocarcinoma from Adenocarcinoma Involving Adenomyosis 2003
- Tamoxifen‐associated postmenopausal adenomyosis exhibits stromal fibrosis, glandular dilatation and epithelial metaplasias 2000
- Pathophysiology of adenomyosis 1998
- Estrogen and Progesterone Receptors of Adenomyosis in Postmenopausal Breast Cancer Patients Treated with Tamoxifen 1998
- Surgical and medical treatment of adenomyosis 1998
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