Adenomyosis in postmenopausal breast cancer patients treated with tamoxifen: a new entity?

I Cohen, Ilan Cohen, Cohen I, Beyth Y, Yoram Beyth, Y Beyth, Tepper R, R. Tepper, Ron Tepper, A Figer, Arié Figer, Figer A, J Shapira, Shapira J, Jeremiah Shapira, Cordoba M, Mario Cordoba, M Cordoba, D Yigael, Dror Yigael, Yigael D, Marco M. Altaras, M M Altaras, Altaras MM
Gynecologic Oncology · 1995 · vol. 58(1) , pp. 86–91 · doi:10.1006/gyno.1995.1188 · PMID:7789896 · W2089595379
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This paper investigates the occurrence of adenomyosis in postmenopausal women with breast cancer who have received tamoxifen treatment.

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Abstract

Between September 1, 1989 and October 31, 1994, 173 postmenopausal breast cancer women on tamoxifen treatment were followed up in the authors' institutions. During this period, 14 (8.1%) underwent total abdominal hysterectomy and bilateral salpingo-oophorectomy for various indications. Eight (57.1%) were found to have adenomyosis, of whom one had a large fundal adenomyotic lump and the other seven patients had two to four small microscopic foci of adenomyosis. In this study, the rate of adenomyosis described among those postmenopausal breast cancer patients treated with tamoxifen is nearly three to four times higher than the rate reported in the literature for pre- and postmenopausal women. There is no previous reported increased incidence of adenomyosis in postmenopausal breast cancer patients treated with tamoxifen. Thus, it is suggested that the prolonged and unopposed estrogen-like stimulation by tamoxifen may play a causal role rather than be a casual factor in the development of this pathologic entity.

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Condition tags

endometriosisadenomyosis

MeSH descriptors

Breast Neoplasms Endometriosis Postmenopause Postmenopause Tamoxifen Adult Adult Aged Aged Breast Neoplasms Breast Neoplasms Endometriosis Endometriosis Endometriosis Female Female Follow-Up Studies Follow-Up Studies Humans Humans

Citation neighborhood (2-hop)

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. Outer rings show 2-hop neighbours — papers reached through the immediate citers/citees. [ collapse to 1-hop ]

Cited by (37)

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