High Frequency of Adenomyosis in Postmenopausal Breast Cancer Patients Treated with Tamoxifen
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Adenomyosis was diagnosed in 53.6% of postmenopausal breast cancer patients treated with tamoxifen, significantly more than the 18.2% in patients not treated with tamoxifen.
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Abstract
Pathologic evaluation for adenomyosis in uterine specimens as well as demographic characteristics, health habits and risk factors for endometrial cancer were compared in 28 postmenopausal breast cancer patients with tamoxifen (TAM) treatment and in 11 similar patients without TAM treatment in order to determine the association between postmenopausal TAM exposure and the frequency of adenomyosis. The same comparison was also made between TAM-treated patients with adenomyosis and TAM-treated patients without adenomyosis. Adenomyosis was histologically diagnosed in 53.6% TAM-treated patients and in 18.2% non-TAM patients. Overall, there were no significant statistical differences in all parameters tested between the 2 groups, as well as between the TAM-treated patients with adenomyosis and the TAM-treated patients without adenomyosis. It can be concluded that adenomyosis was significantly more common among postmenopausal breast cancer patients who were treated with TAM as compared to similar patients without TAM treatment (p = 0.0186). This significant high rate of adenomyosis may be attributed to the continuous and unopposed exposure to TAM. It is, however, impossible to predict which postmenopausal breast cancer patient will develop adenomyosis after treatment with TAM.
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Cited by (40)
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- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- Pathogenesis of Human Adenomyosis: Current Understanding and Its Association with Infertility 2022
- Prevalence of adenomyosis in women undergoing hysterectomy for abnormal uterine bleeding, pelvic pain or uterine prolapse - A retrospective cohort study 2022
- Evaluation of mammographic features in women with adenomyosis 2022
- Evaluation Of Mammographic Features In Women With Adenomyosis 2022
- Insights on Adenomyosis Development 2022
- The Impact of Adenomyosis on Pregnancy and Pregnancy Outcomes: A Review 2022
- Mode Switch of Ca2 + Oscillation-Mediated Uterine Peristalsis and Associated Embryo Implantation Impairments in Mouse Adenomyosis 2021
- Epidemiology of Adenomyosis 2020
- Proteomic Analysis of Uterine Tissues During Peri-Implantation Period in Mice with Experimentally Induced Adenomyosis that Treated with anti-Ngf: Implications for Cell-Cell Adhesion and Metabolic Processes 2020
- Adenomyosis in mice resulting from mechanically or thermally induced endometrial–myometrial interface disruption and its possible prevention 2020
- An Update on the Various Theories of the Origin of Uterine Adenomyosis –A Systematic Review 2020
- Endometriosis in the postmenopausal female: clinical presentation, imaging features, and management 2019
- Adenomyosis and Infertility 2019
- Differential diagnosis of adenomyosis: the role of hysteroscopy and laparoscopy 2019
- Prevalence of Adenomyosis in Hysterectomy Specimen in Jammu Region and its Clinical Correlations in a Tertiary Care Hospital 2019
- Pathogenesis of uterine adenomyosis: invagination or metaplasia? 2018
- Benign Diseases of the Endometrium 2018
- Leonurine Attenuates Hyperalgesia in Mice with Induced Adenomyosis 2017
- The Pathophysiology of Adenomyosis 2015
- The Incidence and Clinical Significance of Adenomyosis 2015
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Diagnóstico de la adenomiosis 2014
- Molecular characterization of human adenomyosis 2006
- Benign Gynecological Diseases and SERMs 2006
- Adénomyose 2006
- Ovarian adenomyoma following gonadotrophin treatment for infertility 2006
- Neonatal tamoxifen treatment of mice leads to adenomyosis but not uterine cancer 2005
- The Role of CD10 Staining in Distinguishing Invasive Endometrial Adenocarcinoma from Adenocarcinoma Involving Adenomyosis 2003
- Ovarian Endometrioid Adenocarcinoma Arising from an Endometriotic Cyst in a Postmenopausal Woman under Tamoxifen Therapy for Breast Cancer: A Case Report 2002
- Tamoxifen treatment and gynecologic side effects: a review 2001
- Adenomyosis—A Result of Disordered Stromal Differentiation 2001
- Prevalence and risk factors of adenomyosis at hysterectomy 2001
- 10.1016/s0246-1064(21)43899-5 2000
- Tamoxifen‐associated postmenopausal adenomyosis exhibits stromal fibrosis, glandular dilatation and epithelial metaplasias 2000
- 10.1016/s0246-1064(13)59690-3 2000
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