Benign Gynecological Diseases and SERMs

In: Selective Estrogen Receptor Modulators · 2006 · pp. 291–311 · doi:10.1007/3-540-34742-9_12 · W939711327
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AI-generated summary by claude@2026-06+body, 2026-06-07

Tamoxifen and raloxifene are clinical SERMs, with tamoxifen used for breast cancer and associated with uterine issues, while raloxifene treats osteoporosis and its uterine effects require further study.

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The paper reviews current clinical use of selective estrogen receptor modulators (SERMs), focusing on tamoxifen and raloxifene, and summarizes evidence on their effects on uterine tissue outcomes and potential relevance to endometriosis. It concludes that tamoxifen’s estrogenic uterine effects are linked to higher endometrial hyperplasia/cancer risk and also to increased uterine leiomyoma dimensions and risk of active endometriotic lesions, while raloxifene has no proven uterine leiomyoma efficacy in normally cycling premenopausal women and is mainly used for post-menopausal osteoporosis; preclinical/experimental SERM potency against leiomyomas and endometriosis is ongoing. A key limitation noted is that evidence for endometriosis efficacy is only potential, with experimental work not yet establishing clinical benefit. Relevance to endometriosis: the paper explicitly states that tamoxifen can increase the risk of developing active endometriotic lesions and that SERM efficacy for endometriosis is only potential, though mainly focused on SERMs overall rather than being an endometriosis trial.

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References

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J Am Med Assoc 279:1445–1451 Yaffe K, Krueger K, Sarkar S, Grady D, Barrett-Connor E, Cox DA, et al. (2001) Cognitive function in postmenopausal women treated with raloxifene. N Engl J Med 344:1207–1213 Yamamoto T, Takamori K, Okada H (1984) Estrogen biosynthesis in leiomyomata and myometrium of the uterus. Horm Metab Res 16:678–679 Author information Authors and Affiliations Editor information Editors and Affiliations Rights and permissions Copyright information © 2006 Springer-Verlag Berlin Heidelberg About this chapter Cite this chapter Palomba, S., Zullo, F. (2006). Benign Gynecological Diseases and SERMs. In: Sanchez, A.C., Calaf i Alsina, J., Dueñas-Díez, JL. (eds) Selective Estrogen Receptor Modulators. Springer, Berlin, Heidelberg . https://doi.org/10.1007/3-540-34742-9_12 Download citation DOI: https://doi.org/10.1007/3-540-34742-9_12 Publisher Name: Springer, Berlin, Heidelberg Print ISBN: 978-3-540-24227-7 Online ISBN: 978-3-540-34742-2 eBook Packages: MedicineMedicine (R0)

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