Adenomyosis in mice resulting from mechanically or thermally induced endometrial–myometrial interface disruption and its possible prevention

Meihua Hao, Liu X, Xishi Liu, Guo SW, Sun-Wei Guo, Sun‐Wei Guo
Reproductive biomedicine online · 2020 · vol. 41(5) , pp. 925–942 · doi:10.1016/j.rbmo.2020.07.023 · PMID:32921577 · W3045743177
article OA: closed CC0 ⤵ 23 in-corpus citations
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⚙ AI-generated summary by claude@2026-06, 2026-06-08 ⓘ

This study investigated how mechanically or thermally disrupting the endometrial-myometrial interface in mice leads to adenomyosis and explored potential preventative measures.

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Abstract

Research questionDo uterine procedures potentially disrupting the endometrial-myometrial interface (EMI) induce adenomyosis?DesignSix prospective, randomized controlled experiments were conducted involving a total of 106 female BALB/c and 12 female C57BL/6 mice. The incidence of adenomyosis was evaluated in these two strains of mouse after mechanically induced EMI disruption (EMID), or thermally induced EMID using electrocoagulation of different intensities. Finally, the incidence was evaluated in mice that had received perioperative administration of aprepitant (an NK1R inhibitor), propranolol (a beta-blocker) or vehicle. Body weight, hot plate latency and grade of myometrial infiltration were evaluated. Histology, immunohistochemistry and histochemistry analyses were also performed.ResultsMechanical injury to the EMI caused EMID. Adenomyosis developed in the majority of mice in the EMID groups 3 months after mechanically induced EMID but did not develop in the control group (83.3% in C57BL/6 mice, P = 0.015; 100% in BALB/c mice, P = 0.0002). With thermally induced EMID, adenomyosis was found in 30% of the EMID mice 10 weeks later, but the incidence increased to 66.7% if the extent of EMID damage was increased. In mice with perioperative administration of aprepitant or propranolol, the incidence of adenomyosis was reduced from 100% to 58.3% (both P = 0.00034).ConclusionsThis study provides the first piece of experimental evidence that EMID resulting from iatrogenic uterine procedures can substantially increase the risk of developing adenomyosis, with the risk in proportion to the severity of disruption. More intriguingly, perioperative administration of an NK1R antagonist or beta-blocker significantly reduced the risk of developing adenomyosis.

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Condition tags

adenomyosis

MeSH descriptors

Adenomyosis Endometrium Endometrium Myometrium Adenomyosis Animals Endometrium Female Mice Mice, Inbred BALB C Mice, Inbred C57BL Myometrium Prospective Studies

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