A murine model of adenomyosis: the effects of hyperprolactinemia induced by fluoxetine hydrochloride, a selective serotonin reuptake inhibitor, on adenomyosis induction in Wistar albino rats.
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Fluoxetine hydrochloride administration induced hyperprolactinemia in rats, leading to adenomyosis development solely in non-castrated animals treated with the drug.
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Abstract
OBJECTIVE: The aim of this study was to investigate whether fluoxetine given to castrated and noncastrated rats caused hyperprolactinemia and its effects with respect to adenomyosis. DESIGN: Fluoxetine, a serotonin reuptake inhibitor, was given to Wistar Albino rats for 98 days to produce hyperprolactinemia. The drug was given to two groups consisting of castrated and noncastrated rats and compared to two groups of castrated and noncastrated controls. Prolactin levels were measured and the uteri of the rats were removed for histopathological analysis at the end of 98 days. SETTING: Marmara University School of Medicine, Department of Histology and Embryology, Zeynep Kamil Women and Children's Hospital. MAIN OUTCOME MEASURES: Serum prolactin levels, uterine histopathology. RESULTS: The prolactin levels of castrated and noncastrated groups treated with fluoxetine were statistically significantly higher when compared to their respective control groups. Histological studies revealed 11 cases of adenomyosis, all within the noncastrated group receiving fluoxetine. CONCLUSION: It was suggested that high serum prolactin levels cause degeneration of myometrial cells in the presence of ovarian steroids that results in a myometrial invasion by endometrial stroma. This invasion eventually progresses to adenomyosis.
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Cited by (19)
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- Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females 2022
- Unveiling the Pathogenesis of Adenomyosis through Animal Models 2022
- Narrative review of hysteroscopy and endometriosis treatment 2021
- Adenomyosis in mice resulting from mechanically or thermally induced endometrial–myometrial interface disruption and its possible prevention 2020
- Benign Uterine Diseases 2019
- Adenomyosis and Infertility 2019
- Effects of Ovarian Pathologies and Uterine Inflammations on Adenomyosis in Bitches 2018
- Corroborating evidence for platelet-induced epithelial-mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis 2016
- Anti-platelet therapy holds promises in treating adenomyosis: experimental evidence 2016
- The Pathophysiology of Adenomyosis 2015
- The Animal Model of Adenomyosis 2015
- Adenomyosis: A Clinical Review of a Challenging Gynecologic Condition 2015
- Transforming growth factor β1 signaling coincides with epithelial–mesenchymal transition and fibroblast-to-myofibroblast transdifferentiation in the development of adenomyosis in mice 2015
- The Possible Role of Fluoxetine in Adenomyosis: An Animal Experiment with Clinical Correlations 2013
- The pathophysiology of uterine adenomyosis: an update 2012
- Understanding adenomyosis: a case control study 2009
- Adenomyosis 2003
- Pathophysiology of adenomyosis 1998
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