The Animal Model of Adenomyosis

In: Uterine Adenomyosis · 2015 · pp. 123–127 · doi:10.1007/978-3-319-13012-5_7 · W2299323489
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Experimental models of adenomyosis in laboratory animals are species and strain dependent, and commonly use neonatal tamoxifen or altered prolactin production in mice, though their functional significance remains unclear.

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This chapter reviews how spontaneous adenomyosis in multiple animal species has been modeled experimentally, emphasizing that induction depends on species/strain and on the timing of hormonal or endocrine interventions. It highlights neonatal tamoxifen administration and altered prolactin production in mice as the most widely reported models, but notes that the functional significance of adenomyosis in these mice and the relevance of the models to human disease remain unclear. A major limitation acknowledged is the difficulty in translating findings because model formation is highly variable across experimental setups and species. This paper is centrally about endometriosis and/or adenomyosis — specifically, it focuses on animal models of adenomyosis and discusses their relevance to human disease.

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Abstract

Spontaneous adenomyosis is known to occur in several animal species and experimental models were developed in laboratory animals through hormonal manipulation. The induction of adenomyosis in laboratory animals is species and strain dependent and is also highly dependent on the exact timing of the intervention. Neonatal administration of tamoxifen and altered prolactin production in the mouse are the models most widely reported in literature but the functional significance of the presence of adenomyosis in the mouse model and the relevance of these models to the human disease remain unclear. Access this chapter Tax calculation will be finalised at checkout Purchases are for personal use only Similar content being viewed by others

References

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Springer, Cham. https://doi.org/10.1007/978-3-319-13012-5_7 Download citation DOI: https://doi.org/10.1007/978-3-319-13012-5_7 Published: Publisher Name: Springer, Cham Print ISBN: 978-3-319-13011-8 Online ISBN: 978-3-319-13012-5 eBook Packages: MedicineMedicine (R0)

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