Induction of uterine adenomyosis by pituitary grafting and retardation of its development by bromocriptine-mesilate (CB-154) in BALB/c mice.

Taketoshi Mori, T Mori, S Kawashima, H Nagasawa
In vivo (Athens, Greece) · 1992 · vol. 5(2) , pp. 107–9 · PMID:1768777 · W2399593713
article OA: closed CC0 ⤵ 6 in-corpus citations
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Pituitary grafting induced adenomyosis in mice, and bromocriptine treatment during youth suppressed its development.

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Abstract

Development of uterine adenomyosis was examined in BALB/c mice. Anterior pituitary (AP) isografting at 8 weeks of age significantly increased the incidence of adenomyosis in mice by 36 weeks of age as compared to that in control mice bearing no AP isograft. However, in mice with AP grafting, daily administration of 0.2 mg bromocriptine-mesilate (CB-154) between 4 and 8 weeks of age decreased the incidence of adenomyosis at 36 weeks of age to the level of control mice. These results suggest that in mice AP grafting stimulates the development of adenomyosis and that pretreatment with CB-154 during youth can suppress the development.

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Condition tags

adenomyosis

MeSH descriptors

Adenoma Bromocriptine Pituitary Gland, Anterior Uterine Neoplasms Adenoma Adenoma Animals Body Weight Bromocriptine Female Mice Mice, Inbred BALB C Organ Size Pituitary Gland, Anterior Uterine Neoplasms Uterine Neoplasms Uterus Uterus

Citation neighborhood

Papers in the corpus that this work cites (lower rings, blue) and that cite this one (upper rings, green). Dot size scales with the paper's in-corpus citation count — bigger dot = more influential within the endo/adeno field. Click a dot to open that paper. [ expand to 2 hops ] — adds papers reached through this work's immediate citers/citees. Heavier; up to 60 extra dots.

Cited by (6)

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